Evidence map›Paper›PMID 37685899›Full record

ArticleInternational journal of molecular sciences2023

Long-Lasting Epigenetic Changes in the Dopamine Transporter in Adult Animals Exposed to Amphetamine during Embryogenesis: Investigating Behavioral Effects.

Tao Ke, Ganesh Ambigapathy, Thanh Ton, Archana Dhasarathy, Lucia Carvelli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tao KeHarriet L. Wilkes Honors College, Florida Atlantic University, Jupiter, FL 33458, USA.ORCID 0000-0001-5805-3189
Ganesh AmbigapathyDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Thanh TonHarriet L. Wilkes Honors College, Florida Atlantic University, Jupiter, FL 33458, USA.
Archana DhasarathyDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Lucia CarvelliHarriet L. Wilkes Honors College, Florida Atlantic University, Jupiter, FL 33458, USA.ORCID 0000-0001-8754-3777
Florida Atlantic University · USUniversity of North Dakota · US

Funding

Amphetamine causes transgenerational effectsR01DA042156 · NIDA · UNIVERSITY OF NORTH DAKOTA · PI CARVELLI, LUCIA · 2016 to 2020
$1.7M
NIDA NIH HHS DA042156NIDA NIH HHS R01 DA042156
6 · The paper itself

Abstract

The dopamine transporter (DAT) is an integral member of the dopaminergic system and is responsible for the release and reuptake of dopamine from the synaptic space into the dopaminergic neurons. DAT is also the major target of amphetamine (Amph). The effects of Amph on DAT have been intensively studied; however, the mechanisms underlying the long-term effects caused by embryonal exposure to addictive doses of Amph remain largely unexplored. As in mammals, in the nematode

Indexed as

AmphetamineDopamine Plasma Membrane Transport ProteinsAnimalsCaenorhabditis elegansDopamineEmbryonic DevelopmentEpigenesis, GeneticMammalsAmphetamineDopamineDopamine Plasma Membrane Transport ProteinsamphetamineC. elegansdopamine transporterepigenetic modificationshistone methylation

Identifiers

PMID37685899
PMCPMC10487411
OpenAlexW4386098596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.