Evidence map›Paper›PMID 37685839›Full record

ArticleInternational journal of molecular sciences2023

Evaluating the Cysteine-Rich and Catalytic Subdomains of Human Tyrosinase and OCA1-Related Mutants Using 1 μs Molecular Dynamics Simulation.

Taariq Woods, Yuri V Sergeev

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Genetic mutations disrupt the coordinated mode of tyrosinase's intra-melanosomal domain.Protein science : a publication of the Protein Society · 2025
    Article
  4. Review
  5. Human recombinant tyrosinase destabilization caused by the double mutation R217Q/R402Q.Protein science : a publication of the Protein Society · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Taariq WoodsNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0005-3837-6956
Yuri V SergeevNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-7204-6572
National Institutes of Health · US

Funding

Proteins From Hereditary Eye Diseases: In-silico and Experimental StudiesZIAEY000476 · NEI · NATIONAL EYE INSTITUTE · PI SERGEEV, YURI · 2009 to 2025
$16.8M
Intramural NIH HHS ZIA EY000476NIH HHS ZIA EY000476-10
6 · The paper itself

Abstract

The inherited disorder oculocutaneous albinism type 1 (OCA1) is caused by mutations in the

Indexed as

CysteineMonophenol MonooxygenaseAlbinism, OculocutaneousHumansMolecular Dynamics SimulationUreaCysteineMonophenol MonooxygenaseUreacysteine-rich and tyrosinase subdomainshomology modelhuman tyrosinasemolecular dynamics simulation of protein urea unfoldingmolten globuleOCA1

Identifiers

PMID37685839
PMCPMC10487697
OpenAlexW4386050981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.