Evidence map›Paper›PMID 37685652›Full record

ReviewJournal of clinical medicine2023

New Developments and Challenges in Liver Transplantation.

Amjad Khalil, Alberto Quaglia, Pierre Gélat, Nader Saffari, Hassan Rashidi, Brian Davidson

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Management of acute liver failure-an updated literature review.World journal of critical care medicine · 2025
    Review
  7. Full Robotic Whole Graft Liver Transplantation: A Novel Approach.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Frontiers in genome editing · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amjad KhalilLiver Unit, Wellington Hospital, London NW8 9TA, UK.ORCID 0000-0001-6689-3516
Alberto QuagliaCancer Institute, University College London, London WC1E 6DD, UK.
Pierre GélatDivision of Surgery and Interventional Science, University College London, London NW3 2PS, UK.
Nader SaffariDepartment of Mechanical Engineering, University College London, London WC1E 7JE, UK.
Hassan RashidiInstitute of Child Health, University College London, London WC1N 1EH, UK.ORCID 0000-0001-8078-6688
Brian DavidsonLiver Unit, Wellington Hospital, London NW8 9TA, UK.
University College London · GBThe Royal Free Hospital · GB

Funding

Rosetrees Trust 2020\100261The Wellington Hospital, HCA London Fellowship and grant
6 · The paper itself

Abstract

Liver disease is increasing in incidence and is the third most common cause of premature death in the United Kingdom and fourth in the United States. Liver disease accounts for 2 million deaths globally each year. Three-quarters of patients with liver disease are diagnosed at a late stage, with liver transplantation as the only definitive treatment. Thomas E. Starzl performed the first human liver transplant 60 years ago. It has since become an established treatment for end-stage liver disease, both acute and chronic, including metabolic diseases and primary and, at present piloting, secondary liver cancer. Advances in surgical and anaesthetic techniques, refined indications and contra-indications to transplantation, improved donor selection, immunosuppression and prognostic scoring have allowed the outcomes of liver transplantation to improve year on year. However, there are many limitations to liver transplantation. This review describes the milestones that have occurred in the development of liver transplantation, the current limitations and the ongoing research aimed at overcoming these challenges.

Indexed as

cell therapyex vivo perfusionhepatocyte transplanthistorylimitationsliver transplantationnonalcoholic fatty liver diseaseorgan preservationregenerative medicinetransplant oncology

Identifiers

PMID37685652
PMCPMC10488676
OpenAlexW4386224189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.