Evidence map›Paper›PMID 37685316›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Utility of the Serum Protein Electrophoresis in the Opportunistic Screening for the Deficiency of Alpha-1 Antitrypsin.

Beatriz Fernández-Gomez, Sebastian Menao-Guillén, Ayla Fernandez Gonzalez, Maria Arruebo Muñio, Monica Ramos Alvarez, Mercedes Inda Landaluce, Maria Angeles Castillo Arce, Miguel Ángel Torralba-Cabeza

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Beatriz Fernández-GomezFaculty of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.
Sebastian Menao-GuillénDepartment of Biochemistry, "Lozano Blesa" University Hospital, 50009 Zaragoza, Spain.
Ayla Fernandez GonzalezDepartment of Biochemistry, "Lozano Blesa" University Hospital, 50009 Zaragoza, Spain.ORCID 0000-0002-0496-411X
Maria Arruebo MuñioDepartment of Biochemistry, "Lozano Blesa" University Hospital, 50009 Zaragoza, Spain.
Monica Ramos AlvarezDepartment of Biochemistry, "Lozano Blesa" University Hospital, 50009 Zaragoza, Spain.
Mercedes Inda LandaluceDepartment of Biochemistry, "Lozano Blesa" University Hospital, 50009 Zaragoza, Spain.
Maria Angeles Castillo ArceDepartment of Biochemistry, "Lozano Blesa" University Hospital, 50009 Zaragoza, Spain.
Miguel Ángel Torralba-CabezaFaculty of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.ORCID 0000-0002-0451-3597
Hospital Clínico Universitario Lozano Blesa · ESUniversidad de Zaragoza · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA deficiency in alpha-1 antitrypsin (AAT1) is a rare disorder that represents a significant health threat and early diagnostic priority issue. We investigated the usefulness of the serum protein electrophoresis (SPE) as an opportunistic screening tool for AAT1 deficiency.

methodsFor 6 months, all SPE carried out for any reasons were evaluated in our center. In those with less than 3% of alpha-1 globulins, AAT1 concentrations were studied. The

resultsOut of the total, 14 patients (0.3%) were identified with low AAT1 concentrations, with 11 of them agreeing to enter the study. Of those, mutations in the

conclusionsAn altered result in the concentration of AAT1 anticipates a mutation in the

Indexed as

alpha-1 antitrypsingenetic counselingprotein electrophoresisscreeningSERPINA1

Identifiers

PMID37685316
PMCPMC10486943
OpenAlexW4386224042

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.