Evidence map›Paper›PMID 37684712›Full record

ArticleMagnetic resonance in medicine2024

In vivo lymph node CEST-Dixon MRI in breast cancer patients with metastatic lymph node involvement.

Manus J Donahue, Paula M C Donahue, R Sky Jones, Maria Garza, Chelsea Lee, Niral J Patel, Andrea Cooper, Jill B De Vis, Ingrid Meszoely, Rachelle Crescenzi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Manus J DonahueDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Paula M C DonahueDepartment of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
R Sky JonesDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Maria GarzaDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Chelsea LeeDepartment of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Niral J PatelDepartment of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Andrea CooperNashville Breast Center, Nashville, Tennessee, USA.
Jill B De VisDepartment of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ingrid MeszoelyDepartment of Surgery, Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Rachelle CrescenziDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-1008-4570
Vanderbilt University Medical Center · USNashville Oncology Associates · USVanderbilt University · US

Funding

Quantification of Glymphatic Dysfunction in Patients with Alzheimer's Disease and Related DementiasR01NR015079 · NINR · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DONAHUE, MANUS J · 2014 to 2022
$3.9M
NINR NIH HHS R01 NR015079
6 · The paper itself

Abstract

purposeAxillary lymph nodes (LNs) often present a reservoir for metastatic breast cancer, yet metastatic LN involvement cannot be discerned definitively using diagnostic imaging. This study investigated whether in vivo CEST may discriminate LNs with versus without metastatic involvement.

methods3T MRI was performed in patients with breast cancer before clinically-indicated mastectomy or lumpectomy with LN removal, after which LN metastasic involvement was determined using histological evaluation. Non-contrast anatomical imaging, as well as B

resultsNo difference in axillary B

conclusionsFindings are consistent with a unique metastatic LN microenvironment detectable by CEST-Dixon and suggest that CEST MRI may have potential for mapping LN metastasis non-invasively in vivo.

Indexed as

Breast NeoplasmsLymphomaAminesBreastFemaleHumansMagnetic Resonance ImagingMastectomyProtonsTumor MicroenvironmentAminesProtonsbreast cancerCESTDixonlymphedemalymph nodemetastasisMRI

Identifiers

PMID37684712
PMCPMC11531103
OpenAlexW4386564715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.