ReviewBMC ophthalmology2023
A rare presentation of orbital spindle cell carcinoma a case report and brief review of the literature.
Review in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- SMARCB1-Deficient Malignant Orbital Neoplasm with Features Overlapping Myxoid Epithelioid Sarcoma: A Diagnostic Challenge.Head and neck pathology · 2026Article
- Refractory Orbital Spindle Cell Carcinoma With Rapid Progression and Intracranial Extension.Case reports in ophthalmological medicine · 2026Article
- Confronting the Unseen: A Journey Through Primary Intra-orbital Squamous Cell Carcinoma.Cureus · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo describe a case of orbital spindle cell carcinoma which presented with limbal ischemia and briefly review the literature.
methodsRetrospective case report and brief literature review.
resultsA 61-year old man presented with blepharoptosis, periorbital pain, decreased vision and limbal ischemia. He did not mention any previous illness and did not take any kind of drugs. Imaging revealed an orbital mass that was positive for SMA, Vimentin and CD99 and negative for S100. We treated the patient with chemotherapy and followed him for other complications that occurred throughout disease course.
conclusionSpindle cell carcinomas are a rare variant of squamous cell carcinoma (SCC) with dual malignant histologic differentiation of squamous and mesenchymal cells. Few cases of orbital spindle cell carcinoma have been reported, which have been either secondary to distant metastasis or regional spread. In this study, we have reported the first case of primary orbital spindle cell carcinoma presenting with limbal ischemia. Further studies are needed to describe the different clinical presentations and management strategies of this rare clinical entity.
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