Evidence map›Paper›PMID 37684541›Full record

ArticleScientific reports2023

Performance evaluation of the AiDx multi-diagnostic automated microscope for the detection of schistosomiasis in Abuja, Nigeria.

Louise Makau-Barasa, Liya Assefa, Moses Aderogba, David Bell, Jacob Solomon, Rita Omohode Urude, Obiageli J Nebe, Juliana A-Enegela, James G Damen, Samuel Popoola and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Louise Makau-BarasaThe Ending Neglected Diseases (END) Fund, New York, USA.
Liya AssefaThe Ending Neglected Diseases (END) Fund, New York, USA.
Moses AderogbaThe Ending Neglected Diseases (END) Fund, New York, USA.
David BellUnaffiliated, Lake Jackson, USA.
Jacob SolomonNTD Division, Federal Ministry of Health, Abuja, Nigeria.
Rita Omohode UrudeNTD Division, Federal Ministry of Health, Abuja, Nigeria.
Obiageli J NebeNTD Division, Federal Ministry of Health, Abuja, Nigeria.
Juliana A-EnegelaCBM International, Cambridge, UK.
James G DamenMedical Lab Department, University of Jos, Jos, Nigeria.
Samuel PopoolaAiDx Medical Bv, Pijnacker, The Netherlands.
Jan-Carel DiehlDelft University of Technology, Delft, The Netherlands.
Gleb VdovineDelft University of Technology, Delft, The Netherlands.
Temitope AgbanaAiDx Medical Bv, Pijnacker, The Netherlands. t.e.agbana@tudelft.nl.
Federal Ministry of Health · NGDelft University of Technology · NLTwente Medical Systems International (Netherlands) · NLUniversity of Jos · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this research, we report on the performance of automated optical digital detection and quantification of Schistosoma haematobium provided by AiDx NTDx multi-diagnostic Assist microscope. Our study was community-based, and a convenient sampling method was used in 17 communities in Abuja Nigeria, based on the disease prevalence information extracted from the baseline database on schistosomiasis, NTD Division, of the Federal Ministry of Health. At baseline, samples from 869 participants were evaluated of which 358 (34.1%) tested S. haematobium positive by the reference diagnostic standard. Registered images from the fully automated (autofocusing, scanning, image registration and processing, AI image analysis and automatic parasite count) AiDx assist microscope were analyzed. The Semi automated (autofocusing, scanning, image registration & processing and manual parasite count) and the fully automated AiDx Assist showed comparable sensitivities and specificities of [90.3%, 98%] and [89%, 99%] respectively. Overall, estimated egg counts of the semi-automated & fully automated AiDx Assist correlated significantly with the egg counts of conventional microscopy (r = 0.93, p ≤ 0.001 and r = 0.89, p ≤ 0.001 respectively). The AiDx Assist device performance is consistent with requirement of the World Health Organization diagnostic target product profile for monitoring, evaluation, and surveillance of Schistosomiasis elimination Programs.

Indexed as

MicroscopySchistosomiasisAnimalsDatabases, FactualHumansNigeriaSchistosoma haematobium

Identifiers

PMID37684541
PMCPMC10491799
OpenAlexW4386558457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.