ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2023
Production of perillic acid from orange essential oil by Yarrowia lipolytica using a top-aerated bioreactor.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A microbial platform for selective biosynthesis of monoterpene esters.Nature communications · 2026Article
- Synthesis, Bioproduction and Bioactivity of Perillic Acid-A Review.Molecules (Basel, Switzerland) · 2025Review
- Cinnamic Acid, Perillic Acid, and Tryptophan Metabolites Differentially Regulate Ion Transport and Serotonin Metabolism and Signaling in the Mouse Ileum In Vitro.International journal of molecular sciences · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
R-(+)-Perillic acid, a promising anticancer and immunomodulatory agent, is the major product from the biotransformation of R-(+)-limonene-rich orange essential oil by the yeast Yarrowia lipolytica. Due to the abundance and low cost of orange essential oil, which is a byproduct of the citrus industry, we attempted to improve the biotransformation process by optimizing yeast cell mass production. Then, the whole process was transposed and adapted to a 2-L instrumented bioreactor. Cell mass production was optimized in shaker flasks using a statistical experimental design. The optimized medium (g·L
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