ArticleThe ISME journal2023
Differential effects of wastewater treatment plant effluents on the antibiotic resistomes of diverse river habitats.
Article in The ISME journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Snowmaking Infrastructure: A Selective Barrier or Potential Vector for Antibiotic Residues and Resistance Determinants in Mountain Catchments.International journal of molecular sciences · 2026Article
- Human wastewater contamination drives the emergence of multidrug-resistant bacteria in the Galápagos marine ecosystem.Nature communications · 2026Article
- Genomic Insight into the Mobility of Antibiotic Resistance Genes in Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Hydrodynamics Shape Antibiotic Resistance in Wastewater-Impacted River Biofilms.Microbial ecology · 2026Article
- Comparative Molecular Characterization of Resistance and Virulence inMicroorganisms · 2026Article
- Metagenomic insights into microbial diversity, xenobiotic and plastic-degrading enzymes in sediments of river Yamuna at Agra.Frontiers in microbiology · 2026Article
- The role of bacteria in wastewater treatment and the impact of treated wastewater on riverine bacterial ecosystems.PloS one · 2026Article
- Metagenomic insights into antibiotic resistance genes and virulence factors in sediments of river Yamuna.Frontiers in microbiology · 2026Article
- Uncovering resistomes in hospital and pharmaceutical industry wastes: insights from shotgun metagenomic profiling.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- The surveillance of antimicrobial resistance in wastewater from a one health perspective: A global scoping and temporal review (2014-2024).One health (Amsterdam, Netherlands) · 2025Article
- A Practical Framework for Environmental Antibiotic Resistance Monitoring in Freshwater Ecosystems.Antibiotics (Basel, Switzerland) · 2025Review
- Occurrence and Risk Assessment of Antimicrobials and Resistant Bacteria in Treated Sewage Effluents in South Brazil.Antibiotics (Basel, Switzerland) · 2025Article
- The risk of pathogenicity and antibiotic resistance in deep-sea cold seep microorganisms.mSystems · 2025Article
- Fish are poor sentinels for surveillance of riverine antimicrobial resistance.One health (Amsterdam, Netherlands) · 2025Article
- Urban wastewater overflows as hotspots for dissemination of bacteria producing extended-spectrum β-lactamases and carbapenemases in the Suquía River, Argentina.Frontiers in microbiology · 2025Article
- Mobile genetic elements and wastewater treatment: contaminants of emerging concern, climate change, and trophic transmission.Frontiers in microbiology · 2025Review
- Integrons in the Age of Antibiotic Resistance: Evolution, Mechanisms, and Environmental Implications: A Review.Microorganisms · 2024Review
- Healthcare waste management and antimicrobial resistance: a critical review.Journal of water and health · 2024Review
- Article
- Unde venis? Bacterial resistance from environmental reservoirs to lettuce: tracking microbiome and resistome over a growth period.FEMS microbiology ecology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wastewater treatment plants (WWTPs) are key sources of antimicrobial resistance genes (ARGs) that could influence the resistomes of microbial communities in various habitats of the receiving river ecosystem. However, it is currently unknown which habitats are most impacted and whether ARGs, like certain chemical contaminants, could be accumulated or enriched in the river ecosystem. We conducted a systematic metagenomic survey on the antibiotic resistomes of WWTP effluent, four riverine habitats (water, suspended particles, sediment, epilithic biofilm), and freshwater amphipod gut microbiomes. The impact of WWTP effluent on the downstream habitats was assessed in nine Swiss rivers. While there were significant differences in resistomes across habitats, the wastewater resistome was more similar to the resistome of receiving river water than to the resistomes of other habitats, and river water was the habitat most strongly impacted by the WWTPs effluent. The sulfonamide, beta-lactam, and aminoglycoside resistance genes were among the most abundant ARGs in the WWTP effluents, and especially aadA, sul1, and class A beta-lactamase genes showed significantly increased abundance in the river water of downstream compared to upstream locations (p < 0.05). However, this was not the case for the sediment, biofilm, and amphipod gut habitats. Accordingly, evidence for accumulation or enrichment of ARGs through the riverine food web was not identified. Our study suggests that monitoring riverine antimicrobial resistance determinants could be conducted using "co-occurrence" of aadA, sul1, and class A beta-lactamase genes as an indicator of wastewater-related pollution and should focus on the water as the most affected habitat.
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Registered trials
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