Evidence map›Paper›PMID 37684488›Full record

ArticlePediatric cardiology2024

Patterns of Electrocardiographic Abnormalities in Children with Hypertrophic Cardiomyopathy.

Mayme Marshall, Aneeq Malik, Maully Shah, Frank A Fish, Susan P Etheridge, Peter F Aziz, Mark W Russell, Svjetlana Tisma, Andreas Pflaumer, Narayanswami Sreeram and 26 more

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 20 institutions in 6 countries.

Mayme MarshallCleveland Clinic Children's Hospital, Cleveland, OH, USA.ORCID http://orcid.org/0000-0003-2076-5476
Aneeq MalikUniversity of Los Angeles Olive View, Los Angeles, CA, USA.
Maully ShahChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Frank A FishVanderbilt University, Nashville, TN, USA.
Susan P EtheridgeUniversity of Utah, Salt Lake City, UT, USA.
Peter F AzizCleveland Clinic Children's Hospital, Cleveland, OH, USA.
Mark W RussellC.S. Mott Children's Hospital, Ann Arbor, MI, USA.
Svjetlana TismaNemours Children's Hospital, Wilmington, DE, USA.
Andreas PflaumerRoyal Children's Hospital, University of Melbourne, Parkville, VIC, Australia.
Narayanswami SreeramUniversity of Cologne, Cologne, Germany.
Peter KubusMotol University, Prague, Czech Republic.
Ian H LawUniversity of Iowa, Iowa City, IA, USA.
Michal J KantochUniversity of Alberta, Edmonton, AB, Canada.
Naomi J KerteszNationwide Children's Hospital, Columbus, OH, USA.
Margaret StrieperChildren's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
Christopher C EricksonChildren's Specialty Physicians, University of Nebraska Medical Center, Omaha, NE, USA.
Jeremy P MooreUniversity of California, Los Angeles, CA, USA.
Stephanie J NakanoUniversity of Colorado, Denver, CO, USA.
Harinder R SinghChildren's Hospital of San Antonio, Baylor College of Medicine, San Antonio, TX, USA.
Philip ChangChildren's Mercy Hospital, Kansas City, MO, USA.
Mitchell CohenInova LJ Murphy Children's Hospital, Falls Church, VA, USA.
Anne FournierUniversity of Montreal, Montreal, QC, Canada.
Maria V IlinaRoyal Children's Hospital, Glasgow, Scotland, UK.
Frank ZimmermannAdvocate Hospital, Chicago, IL, USA.
Michaela HorndaschGerman Heart Center, Munich, Germany.
Walter LiUniversity of California, San Francisco, CA, USA.
Anjan S BatraUniversity of California, Irvine, CA, USA.
Leonardo LibermanColumbia University, New York, NY, USA.
Robert HamiltonHospital for Sick Kids, Toronto, ON, Canada.
Christopher M JansonChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Shubhayan SanataniUniversity of British Columbia, Vancouver, BC, Canada.
Ilana ZeltserUniversity of Texas-Southwestern, Dallas, TX, USA.
George McDanielUniversity of Virginia, Charlottesville, VA, USA.
Andrew D BlaufoxZucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Jason M GarnreiterSaint Louis University, Saint Louis, MO, USA.
Seshadri BalajiOregon Health and Science University, 707 SW Gaines Street, Portland, OR, 97239, USA. balajis@ohsu.edu.ORCID http://orcid.org/0000-0001-5864-5125
Children's Hospital of Philadelphia · USCleveland Clinic · USBaylor College of Medicine · USChildren's Mercy Hospital · USColumbia University · USC. S. Mott Children's Hospital · USDeutsches Herzzentrum München · DEEmory University · USHofstra University · USHospital for Sick Children · CANationwide Children's Hospital · USNebraska Medical Center · USOlive View-UCLA Medical Center · USOregon Health & Science University · USRoyal Children's Hospital · AURoyal Hospital for Children · GBSaint Louis University · USThe University of Texas Southwestern Medical Center · USUniversité de Montréal · CAUniversity Hospital in Motol · CZ

Funding

Medtronic External Research Program Protocol #1651
6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM), a common cardiomyopathy in children, is an important cause of morbidity and mortality. Early recognition and appropriate management are important. An electrocardiogram (ECG) is often used as a screening tool in children to detect heart disease. The ECG patterns in children with HCM are not well described.ECGs collected from an international cohort of children, and adolescents (≤ 21 years) with HCM were reviewed. 482 ECGs met inclusion criteria. Age ranged from 1 day to 21 years, median 13 years. Of the 482 ECGs, 57 (12%) were normal. The most common abnormalities noted were left ventricular hypertrophy (LVH) in 108/482 (22%) and biventricular hypertrophy (BVH) in 116/482 (24%) Of the patients with LVH/BVH (n = 224), 135 (60%) also had a strain pattern (LVH in 83, BVH in 52). Isolated strain pattern (in the absence of criteria for hypertrophy) was seen in 43/482 (9%). Isolated pathologic Q waves were seen in 71/482 (15%). Pediatric HCM, 88% have an abnormal ECG. The most common ECG abnormalities were LVH or BVH with or without strain. Strain pattern without hypertrophy and a pathologic Q wave were present in a significant proportion (24%) of patients. Thus, a significant number of children with HCM have ECG abnormalities that are not typical for "hypertrophy". The presence of the ECG abnormalities described above in a child should prompt further examination with an echocardiogram to rule out HCM.

Indexed as

Cardiomyopathy, HypertrophicElectrocardiographyHypertrophy, Left VentricularAdolescentChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleRetrospective StudiesYoung AdultElectrocardiogramHypertrophic cardiomyopathyLeft ventricular hypertrophyPediatricStrainSudden death

Identifiers

PMID37684488
OpenAlexW4386564588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.