Evidence map›Paper›PMID 37684421›Full record

ArticleJournal of the Association for Research in Otolaryngology : JARO2023

Sheep as a Large-Animal Model for Otology Research: Temporal Bone Extraction and Transmastoid Facial Recess Surgical Approach.

Nicholas A Waring, Alexander Chern, Brandon J Vilarello, Jeffrey H Lang, Elizabeth S Olson, Hideko Heidi Nakajima

Open access · greenAbstract read
In one paragraph

Article in Journal of the Association for Research in Otolaryngology : JARO, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. The ovine temporal bone for otologic surgery training: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. Article
  3. Comparison of Inner Ear Volume Between Humans and Sheep Using MRI.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Article
  4. Article
  5. Hampshire Sheep as a Large-Animal Model for Cochlear Implantation.Journal of the Association for Research in Otolaryngology : JARO · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nicholas A WaringVagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Alexander Chern *Department of Otolaryngology-Head & Neck Surgery, NewYork-Presbyterian/Columbia University Irving Medical Center, NY, New York, USA.
Brandon J Vilarello *Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jeffrey H LangDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Elizabeth S OlsonDepartment of Otolaryngology-Head & Neck Surgery, NewYork-Presbyterian/Columbia University Irving Medical Center, NY, New York, USA. eao2004@cumc.columbia.edu.ORCID 0000-0002-3586-7769
Hideko Heidi NakajimaDepartment of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
Columbia University Irving Medical Center · USMassachusetts Eye and Ear Infirmary · USMassachusetts Institute of Technology · US

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3M
Implantable Microphones for Fully Implantable Hearing ProstheticsR01DC016874 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI LANG, JEFFREY H, NAKAJIMA, HIDEKO HEIDI · 2019 to 2023
$1.8M
NCI NIH HHS P30 CA013696NIDCD NIH HHS R01 DC016874
6 · The paper itself

Abstract

purposeSheep are used as a large-animal model for otology research and can be used to study implantable hearing devices. However, a method for temporal bone extraction in sheep, which enables various experiments, has not been described, and literature on middle ear access is limited. We describe a method for temporal bone extraction and an extended facial recess surgical approach to the middle ear in sheep.

methodsTen temporal bones from five Hampshire sheep head cadavers were extracted using an oscillating saw. After craniotomy and removal of the brain, a coronal cut was made at the posterior aspect of the orbit followed by a midsagittal cut of the occipital bone and disarticulation of the atlanto-occipital joint. Temporal bones were surgically prepared with an extended facial recess approach. Micro-CT scans of each temporal bone were obtained, and anatomic dimensions were measured.

resultsTemporal bone extraction was successful in 10/10 temporal bones. Extended facial recess approach exposed the malleus, incus, stapes, and round window while preserving the facial nerve, with the following surgical considerations: minimally pneumatized mastoid; tegmen (superior limit of mastoid cavity) is low-lying and sits below temporal artery; chorda tympani sacrificed to optimize middle ear exposure; incus buttress does not obscure view of middle ear. Distance between the superior aspect of external auditory canal and tegmen was 2.7 (SD 0.9) mm.

conclusionWe identified anatomic landmarks for temporal bone extraction and describe an extended facial recess approach in sheep that exposes the ossicles and round window. This approach is feasible for studying implantable hearing devices.

Indexed as

OtolaryngologyTemporal BoneAnimalsEar, MiddleMastoidRound Window, EarSheepFacial recessImplantable hearing prostheticsMiddle earSheepTemporal bone

Identifiers

PMID37684421
PMCPMC10695901
OpenAlexW4386537508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.