Evidence map›Paper›PMID 37684407›Full record

ReviewOncogene2023

Translation of AI into oncology clinical practice.

Issam El Naqa, Aleksandra Karolak, Yi Luo, Les Folio, Ahmad A Tarhini, Dana Rollison, Katia Parodi

Abstract readReview
In one paragraph

Review in Oncogene, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Issam El NaqaDepartment of Machine Learning, Moffitt Cancer Center, Tampa, FL, 33612, USA. issam.elnaqa@moffitt.org.ORCID 0000-0001-6023-1132
Aleksandra KarolakDepartment of Machine Learning, Moffitt Cancer Center, Tampa, FL, 33612, USA.ORCID 0000-0001-8430-7138
Yi LuoDepartment of Machine Learning, Moffitt Cancer Center, Tampa, FL, 33612, USA.ORCID 0000-0003-2519-5900
Les FolioDiagnostic Imaging & Interventional Radiology, Moffitt Cancer Center, Tampa, FL, 33612, USA.
Ahmad A TarhiniCutaneous Oncology and Immunology, Moffitt Cancer Center, Tampa, FL, 33612, USA.
Dana RollisonDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, 33612, USA.
Katia ParodiDepartment of Medical Physics, Ludwig-Maximilians-Universität München, Munich, Germany.
Moffitt Cancer Center · USLudwig-Maximilians-Universität München · DE

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Optimal Decision Making in Radiotherapy Using Panomics AnalyticsR01CA233487 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EL NAQA, ISSAM M. · 2019 to 2023
$2.4M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA233487
6 · The paper itself

Abstract

Artificial intelligence (AI) is a transformative technology that is capturing popular imagination and can revolutionize biomedicine. AI and machine learning (ML) algorithms have the potential to break through existing barriers in oncology research and practice such as automating workflow processes, personalizing care, and reducing healthcare disparities. Emerging applications of AI/ML in the literature include screening and early detection of cancer, disease diagnosis, response prediction, prognosis, and accelerated drug discovery. Despite this excitement, only few AI/ML models have been properly validated and fewer have become regulated products for routine clinical use. In this review, we highlight the main challenges impeding AI/ML clinical translation. We present different clinical use cases from the domains of radiology, radiation oncology, immunotherapy, and drug discovery in oncology. We dissect the unique challenges and opportunities associated with each of these cases. Finally, we summarize the general requirements for successful AI/ML implementation in the clinic, highlighting specific examples and points of emphasis including the importance of multidisciplinary collaboration of stakeholders, role of domain experts in AI augmentation, transparency of AI/ML models, and the establishment of a comprehensive quality assurance program to mitigate risks of training bias and data drifts, all culminating toward safer and more beneficial AI/ML applications in oncology labs and clinics.

Identifiers

PMID37684407
PMCPMC12516697
OpenAlexW4386545809

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.