ArticleInternational journal of obesity (2005)2023
Relative fat mass and prediction of incident atrial fibrillation, heart failure and coronary artery disease in the general population.
Article in International journal of obesity (2005), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 31 citations in OpenAlex.
- Update on Obesity and Its Relationship to Atherosclerotic Cardiovascular Disease and Associated Risk Factors.Journal of clinical medicine · 2026Review
- Association between relative fat mass and chronic cardiorenal syndrome: A cross-sectional study based on NHANES 1999 to 2018.Medicine · 2026Article
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- The combination of visceral adiposity and triglyceride-glucose indices as predictors of cardiovascular disease incidence in middle-aged and older adults.European journal of medical research · 2026Article
- Relative fat mass and cardiovascular risk in Peruvian adults: Findings from a national survey.PloS one · 2026Article
- Relative fat mass and cardiovascular risk in Chinese adults: a nationwide prospective cohort study.Nutrition journal · 2025Article
- Joint association of triglyceride glucose index and relative fat mass with new-onset cardiovascular events: a prospective study from CHARLS.Lipids in health and disease · 2025Article
- Association of novel obesity indexes with cognitive impairment: a cross-sectional study of a low-income population in rural China in 2014.BMC public health · 2025Article
- Association and discriminative performance of relative fat mass for frailty index in US older adultsoxy_comment_end.Scientific reports · 2025Article
- Body roundness index vs. Relative fat mass: associations with cardiovascular-kidney-metabolic syndrome in a cross-sectional study.Diabetology & metabolic syndrome · 2025Article
- Association Between Relative Fat Mass and Cardiometabolic Disease: Age-Stratified Analysis in Young and Middle-Aged Versus Older Adults.Reviews in cardiovascular medicine · 2025Article
- Relative Fat Mass: Refining Adiposity Measurement in the Era Beyond Body Mass Index.Current heart failure reports · 2025Review
- Association of relative fat mass with female infertility: a cross-sectional study based on NHANES 2017-2020.Scientific reports · 2025Article
- Association of relative fat mass with female infertility: a cross-sectional study based on NHANES 2017-2020.Scientific reports · 2025Article
- Higher relative fat mass was associated with a higher prevalence of gallstones in US adults.BMC gastroenterology · 2025Article
- Association of relative fat mass with asthma: inflammatory markers as potential mediators.Lipids in health and disease · 2025Article
- Relative Fat Mass and Psoriasis Risk: Evidence from NHANES 2009-2014.Journal of multidisciplinary healthcare · 2025Article
- Interplay between sex, age, BMI, health-related quality of life, and coping strategies in amateur and professional athletes.Frontiers in physiology · 2025Article
- Association of Body Mass Index with Echocardiographic Parameters and Incidence of Left Atrial Thrombus or Spontaneous Echo Contrast in Patients with Nonvalvular Atrial Fibrillation: A Cross-Sectional Study.Reviews in cardiovascular medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRelative fat mass (RFM) is an emerging marker of obesity that estimates body fat percentage using a sex-specific formula containing height and waist circumference (WC). We studied the association of RFM with incident atrial fibrillation (AF), heart failure (HF), and coronary artery disease (CAD) and explored RFM cutoffs for cardiovascular disease (CVD) prediction.
methodsWe studied 95,003 participants (age 45 ± 13 years, 59% women) without prevalent AF, HF or CAD from the population-based Lifelines study. Outcomes were ascertained using electrocardiography and self-reported questionnaire data. We used logistic regression to study the association of RFM with individual outcomes and a composite outcome (incident AF, HF, and/or CAD). Multivariable models were adjusted for components of the SCORE risk model (age, sex, systolic blood pressure, cholesterol, and smoking). Optimal cutoffs were determined using the Youden index.
resultsDuring a median follow-up of 3.8 (3.0-4.6) years, 224 (0.2%) participants developed AF, 1003 (1.1%) HF and 657 (0.7%) CAD. After multivariable adjustment, RFM was significantly associated with all outcomes (standardised OR 1.26, 95% CI 1.18-1.34 for the composite outcome). Optimal RFM cutoffs ( ≥26 for men, ≥38 for women) were lower than previously proposed RFM cutoffs ( ≥30 for men, ≥40 for women). In general, overall discriminative ability of RFM and its cutoffs was at least similar (in women) or better (in men) compared to BMI and WC. Since RFM was substantially correlated with age, we additionally determined age-specific cutoffs, which ranged from 23 to 27 in men and 33 to 43 in women.
conclusionsRFM is associated with incident AF, HF, and CAD and may be used as a simple and intuitive marker of obesity and cardiovascular risk in the general population. This study provides potential RFM cutoffs for CVD prediction that may be used by future studies or preventive strategies targeting obesity and cardiovascular risk.
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