ArticleNature communications2023
Understanding the mechanism of red light-induced melatonin biosynthesis facilitates the engineering of melatonin-enriched tomatoes.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Plant-Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two-Component System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tomato NAC2-DREB2 module fine-tunes saline-alkali stress sensitivity via modulation of melatonin biosynthesis and ROS homeostasis.Horticulture research · 2026Article
- Tandem MADS-Box Genes FUL2 and MADS1 Form a Regulatory Module to Repress Serotonin Biosynthesis via Direct ASMT5 Activation in Tomato Fruit.Plant biotechnology journal · 2026Article
- Identification and Regulation of Melatonin Biosynthetic Genes in Sweet Pepper During Ripening and Melatonin Treatment.Antioxidants (Basel, Switzerland) · 2026Article
- Fine-mapping reveals BcNAC153 act as a negative regulator controlling high temperature tolerance in Brassica rapa.Molecular horticulture · 2026Article
- Integrated transcriptomic and metabolomic analyses reveal light-quality-dependent regulation of specialized metabolism in Pseudostellaria heterophylla.BMC genomics · 2026Article
- Light regulates tomato fruit metabolome via SlDML2-mediated global DNA demethylation.Journal of integrative plant biology · 2026Article
- Melatonin microbe interactions in plant rhizosphere.iScience · 2025Review
- Engineering hormonal crosstalk to enhance serotonin/melatonin levels in rice.Nature communications · 2025Article
- Melatonin and Grain Legume Crops: Opportunities for Abiotic Stress Tolerance Enhancement and Food Sustainability.Plants (Basel, Switzerland) · 2025Review
- Functional interactions among H2O2, NO, H2S, and melatonin in the physiology, metabolism, and quality of horticultural Solanaceae.Journal of experimental botany · 2025Review
- Plant synthetic biology-based biofortification, strategies and recent progresses.Journal of integrative plant biology · 2025Review
- Nanoselenium application improves post-harvest fruit quality and disease resistance in tomato.The Plant journal : for cell and molecular biology · 2025Article
- Melatonin Enhances Panax vietnamensis Resistance to Leaf Blight Pathogen Neofusicoccum ribis via the PvWRKY40-PvCOMT2 Module-Driven Lignin Biosynthesis.Molecular plant pathology · 2025Article
- Advanced technologies in plant factories: exploring current and future economic and environmental benefits in urban horticulture.Horticulture research · 2025Article
- Review
- Clock protein LHY targetsScience advances · 2024Article
- Loss of cold tolerance is conferred by absence of the WRKY34 promoter fragment during tomato evolution.Nature communications · 2024Article
- Photoperiod-Dependent Nutrient Accumulation in Rice Cultivated in Plant Factories: A Comparative Metabolomic Analysis.Foods (Basel, Switzerland) · 2024Article
- Elucidating the role of exogenous melatonin in mitigating alkaline stress in soybeans across different growth stages: a transcriptomic and metabolomic approach.BMC plant biology · 2024Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melatonin is a functionally conserved broad-spectrum physiological regulator found in most biological organisms in nature. Enrichment of tomato fruit with melatonin not only enhances its agronomic traits but also provides extra health benefits. In this study, we elucidate the full melatonin biosynthesis pathway in tomato fruit by identifying biosynthesis-related genes that encode caffeic acid O-methyltransferase 2 (SlCOMT2) and N-acetyl-5-hydroxytryptamine-methyltransferases 5/7 (SlASMT5/7). We further reveal that red light supplementation significantly enhances the melatonin content in tomato fruit. This induction relies on the "serotonin-N-acetylserotonin-melatonin" biosynthesis route via the SlphyB2-SlPIF4-SlCOMT2 module. Based on the regulatory mechanism, we design a gene-editing strategy to target the binding motif of SlPIF4 in the promoter of SlCOMT2, which significantly enhances the production of melatonin in tomato fruit. Our study provides a good example of how the understanding of plant metabolic pathways responding to environmental factors can guide the engineering of health-promoting foods.
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