ArticleScientific reports2023
Real-world analysis of survival benefit of surgery and adjuvant therapy in elderly patients with colorectal cancer.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 25 citations in OpenAlex.
- Development and internal validation of a prognostic nomogram for cancer-specific survival among elderly unresected colorectal cancer patients receiving chemotherapy: a retrospective SEER database study.Translational cancer research · 2026Article
- Bridging the Evidence Gap: A Retrospective Lens on Survival and Treatment Patterns in Older Patients With Colorectal Cancer.Saudi medical journal · 2026Article
- Long-term Outcomes of Endoscopic and Surgical Resection for High-risk pT1 Colorectal Cancer in Elderly Patients.Journal of the anus, rectum and colon · 2026Article
- Impact of anesthesia methods on adverse cardiovascular events during painless gastroscopy in frail older patients: study protocol for a prospective controlled trial.Frontiers in medicine · 2026Article
- Frailty Recovery Following Minimally Invasive Surgery: An Emerging Perspective on Surgical Benefits in Elderly Colorectal Cancer Patients.Annals of gastroenterological surgery · 2026Article
- Impact of age on short-term outcomes and oncologic prognosis after radical surgery for colorectal cancer over 60.International journal of colorectal disease · 2025Article
- Chemotherapy and age stratified survival outcomes in colorectal cancer based on a population analysis from the surveillance epidemiology and end results program 2010 to 2020.Discover oncology · 2025Article
- Outcomes Following Colorectal Cancer Resection in Elderly Patients.Current oncology (Toronto, Ont.) · 2025Article
- Surgical treatment of colorectal cancer: A multidimensional review.World journal of gastrointestinal surgery · 2025Review
- Nomogram models for predicting lymph node metastasis and prognosis in early gastric cancer 60 or older: a population-based cohort study.Discover oncology · 2025Article
- Competing risk and random survival forest models for predicting survival in post-resection elderly stage I-III colorectal cancer patients.Scientific reports · 2025Article
- Renal Function Deterioration in Postoperative (Adjuvant) Chemotherapy for Colon Cancer-Real-Life Data.Current oncology (Toronto, Ont.) · 2025Article
- Circulating tryptophan-kynurenine pathway metabolites are associated with all-cause mortality among patients with stage I-III colorectal cancer.International journal of cancer · 2025Article
- Adjuvant Chemotherapy in Colon Cancer: Simple is Better… Less is More.South Asian journal of cancer · 2024Review
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment guidelines for colorectal cancer (CRC) in elderly patients remain unclear. This study aimed to investigate whether elderly patients (≥ 70 years) with CRC benefit from surgery and adjuvant therapy. A total of 90,347 eligible CRC patients older than 70 years were collected from the Surveillance, Epidemiology, and End Results (SEER) database and divided into a surgery group and a no-surgery group. After being matched by propensity score matching at a 1:1 ratio, 23,930 patients were included in our analysis. The Kaplan‒Meier method and log-rank test were applied to compare overall survival (OS) and cancer-specific survival (CSS). Univariate and multivariate Cox regression analyses were utilized to confirm independent prognostic factors for OS and CSS. In age-stratified analysis (70-74; 75-79; 80-84; ≥ 85), the OS and CSS rates of patients in the surgery group were significantly higher than those of patients in the no-surgery group (all P < 0.001). Adjuvant therapy was an independent prognostic factor for OS and CSS in elderly patients with CRC (all P < 0.001). Further analysis showed that elderly colon cancer patients with stage III and stage IV disease gained a survival benefit from adjuvant chemotherapy. Adjuvant chemoradiotherapy can significantly improve OS and CSS in elderly rectal cancer patients with stage II, III, and IV disease. In conclusion, among CRC patients aged ≥ 70 years reported in the SEER database, treatment with surgical resection is significantly associated with improved OS and CSS. Moreover, adjuvant therapy led to a significant prognostic advantage for elderly advanced CRC patients who underwent surgery.
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