Evidence map›Paper›PMID 37684238›Full record

ArticleCell death & disease2023

Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells.

Flore Sneyers, Martijn Kerkhofs, Femke Speelman-Rooms, Kirsten Welkenhuyzen, Rita La Rovere, Ahmed Shemy, Arnout Voet, Guy Eelen, Mieke Dewerchin, Stephen W G Tait and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Flore SneyersKU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Campus Gasthuisberg O&N I, Herestraat 49 box 802, 3000, Leuven, Belgium.ORCID 0000-0003-0329-7973
Martijn KerkhofsKU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Campus Gasthuisberg O&N I, Herestraat 49 box 802, 3000, Leuven, Belgium.ORCID 0000-0003-2497-9244
Femke Speelman-RoomsKU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Campus Gasthuisberg O&N I, Herestraat 49 box 802, 3000, Leuven, Belgium.
Kirsten WelkenhuyzenKU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Campus Gasthuisberg O&N I, Herestraat 49 box 802, 3000, Leuven, Belgium.
Rita La RovereKU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Campus Gasthuisberg O&N I, Herestraat 49 box 802, 3000, Leuven, Belgium.
Ahmed ShemyKU Leuven, Laboratory for Biomolecular Modelling and Design, Department of Chemistry, Celestijnenlaan 200G, 3001, Heverlee, Belgium.
Arnout VoetKU Leuven, Laboratory for Biomolecular Modelling and Design, Department of Chemistry, Celestijnenlaan 200G, 3001, Heverlee, Belgium.
Guy EelenKU Leuven, Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, Leuven Cancer Institute, Campus Gasthuisberg O&N4, Herestraat 49 box 912, Leuven, Belgium.ORCID 0000-0003-3354-5819
Mieke DewerchinKU Leuven, Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, Leuven Cancer Institute, Campus Gasthuisberg O&N4, Herestraat 49 box 912, Leuven, Belgium.ORCID 0000-0002-0382-9346
Stephen W G TaitCancer Research UK Beatson Institute, School of Cancer Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0001-7697-132X
Bart GhesquièreKU Leuven, Laboratory of Applied Mass Spectrometry, Department of Cellular and Molecular Medicine, Leuven, Belgium - VIB, Metabolomics Core Facility Leuven, Center for Cancer Biology, Leuven, Belgium, Herestraat 49 box 912, 3000, Leuven, Belgium.
Martin D BootmanSchool of Life, Health and Chemical Sciences, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK. martin.bootman@open.ac.uk.ORCID 0000-0002-6447-3451
Geert BultynckKU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Campus Gasthuisberg O&N I, Herestraat 49 box 802, 3000, Leuven, Belgium. geert.bultynck@kuleuven.be.ORCID 0000-0002-5968-4828
KU Leuven · BEVIB-KU Leuven Center for Cancer Biology · BECancer Research UK Scotland Institute · GBThe Open University · GBUniversitair Ziekenhuis Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular Ca

Indexed as

NeoplasmsPhosphoric Monoester HydrolasesEgtazic AcidMyeloid Cell Leukemia Sequence 1 ProteinPhosphofructokinase-21,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acidEgtazic AcidMyeloid Cell Leukemia Sequence 1 ProteinPhosphofructokinase-2Phosphoric Monoester Hydrolases

Identifiers

PMID37684238
PMCPMC10491774
OpenAlexW4386545321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.