Evidence map›Paper›PMID 37684045›Full record

ArticleLife science alliance2023

Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation.

Robert M Bragg, Sydney R Coffey, Jeffrey P Cantle, Shikai Hu, Sucha Singh, Samuel Rw Legg, Cassandra A McHugh, Amreen Toor, Scott O Zeitlin, Seung Kwak and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Robert M BraggBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.ORCID https://orcid.org/0000-0003-0619-8954
Sydney R CoffeyBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.ORCID https://orcid.org/0000-0002-1477-2197
Jeffrey P CantleBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Shikai HuSchool of Medicine, Tsinghua University, Beijing, China.
Sucha SinghDivision of Experimental Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Samuel Rw LeggBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Cassandra A McHughBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Amreen ToorBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA.
Scott O ZeitlinDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.ORCID https://orcid.org/0000-0003-1054-3343
Seung KwakCHDI Foundation, Princeton, NJ, USA.
David HowlandCHDI Foundation, Princeton, NJ, USA.
Thomas F VogtCHDI Foundation, Princeton, NJ, USA.
Satdarshan P MongaDivision of Experimental Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-8437-3378
Jeffrey B CarrollBehavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA jeffcarr@uw.edu.ORCID https://orcid.org/0000-0003-1711-8868
Western Washington University · USCHDI Foundation · USUniversity of Pittsburgh · USCharlottesville Medical Research · USUniversity of Washington · US

Funding

Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shuchang Silvia Liu · 2019 to 2026
$10.9M
Role of Wnt/Beta-Catenin Signaling in Liver DevelopmentR01DK062277 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Satdarshan Singh Monga · 2004 to 2026
$9.0M
Role and regulation of beta-catenin in cholestatic liver diseaseR01DK103775 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Satdarshan Singh Monga, Kari N Nejak-Bowen · 2015 to 2026
$4.8M
Investigating Multifactorial Beta-catenin Activation in Hepatocellular CancersR01CA250227 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Xin Chen, Satdarshan Singh Monga · 2021 to 2026
$3.0M
Understanding the mechanisms that modulate the effects of mutant Huntingtin lowering in aging Huntington's disease model miceR01NS124728 · NINDS · UNIVERSITY OF VIRGINIA · PI Scott Zeitlin · 2022 to 2026
$2.1M
NCI NIH HHS R01 CA250227NIDDK NIH HHS P30 DK120531NIDDK NIH HHS R01 DK062277NIDDK NIH HHS R01 DK103775NINDS NIH HHS R01 NS124728
6 · The paper itself

Abstract

Huntington's disease arises from a toxic gain of function in the

Indexed as

HepatocytesLiverAcetaminophenAnimalsMicePhenotypeAcetaminophen

Identifiers

PMID37684045
PMCPMC10488683
OpenAlexW4386563859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.