Evidence map›Paper›PMID 37683886›Full record

ArticleNeuropharmacology2023

Volatile anesthetics inhibit presynaptic cGMP signaling to depress presynaptic excitability in rat hippocampal neurons.

Iris Speigel, Kishan Patel, Vanessa Osman, Hugh C Hemmings

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Zoological research · 2024
    Article
  3. The Interplay between cGMP and Calcium Signaling in Alzheimer's Disease.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Iris SpeigelDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, 10065, USA.
Kishan PatelDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, 10065, USA.
Vanessa OsmanDepartment of Pharmacology, Weill Cornell Medicine, New York, NY, 10065, USA.
Hugh C HemmingsDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, 10065, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY, 10065, USA. Electronic address: hchemmi@med.cornell.edu.
Cornell University · US

Funding

SYNAPTIC MECHANISMS OF GENERAL ANESTHETIC ACTIONR01GM058055 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HEMMINGS, HUGH C · 1998 to 2023
$10.1M
The Effect of Isoflurane on Axonal Endoplasmic Reticulum Ca2+ Dynamics in Hippocampal NeuronsF31GM133115 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI OSMAN, VANESSA · 2019 to 2021
$137k
NIGMS NIH HHS F31 GM133115NIGMS NIH HHS R01 GM058055
6 · The paper itself

Abstract

Volatile anesthetics alter presynaptic function through effects on Ca

Indexed as

Anesthetics, InhalationIsofluraneAnimalsCyclic GMPGlutamic AcidHippocampusNeuronsRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSevofluraneSynaptophysinAnesthetics, InhalationCyclic GMPGlutamic AcidIsofluraneReceptors, N-Methyl-D-AspartateSevofluraneSynaptophysinCyclic GMPHCN channelIsofluraneMechanisms of anesthesiaNeurotransmitter releaseNitric oxideSevofluraneSynaptic transmission

Identifiers

PMID37683886
PMCPMC10772825
OpenAlexW4386470026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.