Evidence map›Paper›PMID 37683763›Full record

ArticleBrain stimulation

Sub-harmonic entrainment of cortical gamma oscillations to deep brain stimulation in Parkinson's disease: Model based predictions and validation in three human subjects.

James J Sermon, Maria Olaru, Juan Ansó, Stephanie Cernera, Simon Little, Maria Shcherbakova, Rafal Bogacz, Philip A Starr, Timothy Denison, Benoit Duchet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

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  4. Rhythmic stimulation elicits multiple, concurrent neural responses.Cerebral cortex (New York, N.Y. : 1991) · 2026
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  9. Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026
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  17. Finely Tuned γ Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain-Sense Study.Movement disorders : official journal of the Movement Disorder Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

James J SermonInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK; MRC Brain Networks Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Maria OlaruDepartment of Neurological Surgery, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Juan AnsóDepartment of Neurological Surgery, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Stephanie CerneraDepartment of Neurological Surgery, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Simon LittleDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Maria ShcherbakovaDepartment of Neurological Surgery, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Rafal BogaczMRC Brain Networks Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Philip A StarrDepartment of Neurological Surgery, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Timothy DenisonInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK; MRC Brain Networks Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Benoit DuchetMRC Brain Networks Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: benoit.duchet@ndcn.ox.ac.uk.
University of California, San Francisco · USUniversity of Oxford · GB

Funding

Accelerating Dissemination of Implantable Neurotechnology for Clinical ResearchU24NS113637 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BORTON, DAVID ALLENSON, DENISON, TIMOTHY · 2020 to 2024
$4.4M
Closed Loop Deep Brain Stimulation for Parkinson's DiseaseUH3NS100544 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STARR, PHILIP ANDREW · 2016 to 2022
$4.1M
The motor network in Parkinson's disease: Mechanisms of therapyR01NS090913 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STARR, PHILIP ANDREW · 2014 to 2023
$3.3M
Optimizing Pharmacotherapy with Noninvasive Wearable Sensors and Subscalp EEGUH3NS123066 · NINDS · MAYO CLINIC ROCHESTER · PI Benjamin H Brinkmann, Gregory A Worrell · 2025 to 2026
$1.4M
Uncovering the neurophysiology of motivation in Parkinson™s disease with implanted adaptive brain stimulationK23NS120037 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LITTLE, SIMON · 2021 to 2024
$809k
Medical Research Council MC_UU_00003/1Medical Research Council MC_UU_00003/3NINDS NIH HHS K23 NS120037NINDS NIH HHS R01 NS090913NINDS NIH HHS U24 NS113637NINDS NIH HHS UH3 NS100544NINDS NIH HHS UH3 NS123066
6 · The paper itself

Abstract

objectivesThe exact mechanisms of deep brain stimulation (DBS) are still an active area of investigation, in spite of its clinical successes. This is due in part to the lack of understanding of the effects of stimulation on neuronal rhythms. Entrainment of brain oscillations has been hypothesised as a potential mechanism of neuromodulation. A better understanding of entrainment might further inform existing methods of continuous DBS, and help refine algorithms for adaptive methods. The purpose of this study is to develop and test a theoretical framework to predict entrainment of cortical rhythms to DBS across a wide range of stimulation parameters. MATERIALS AND

methodsWe fit a model of interacting neural populations to selected features characterising PD patients' off-stimulation finely-tuned gamma rhythm recorded through electrocorticography. Using the fitted models, we predict basal ganglia DBS parameters that would result in 1:2 entrainment, a special case of sub-harmonic entrainment observed in patients and predicted by theory.

resultsWe show that the neural circuit models fitted to patient data exhibit 1:2 entrainment when stimulation is provided across a range of stimulation parameters. Furthermore, we verify key features of the region of 1:2 entrainment in the stimulation frequency/amplitude space with follow-up recordings from the same patients, such as the loss of 1:2 entrainment above certain stimulation amplitudes.

conclusionOur results reveal that continuous, constant frequency DBS in patients may lead to nonlinear patterns of neuronal entrainment across stimulation parameters, and that these responses can be predicted by modelling. Should entrainment prove to be an important mechanism of therapeutic stimulation, our modelling framework may reduce the parameter space that clinicians must consider when programming devices for optimal benefit.

Indexed as

Deep Brain StimulationParkinson DiseaseBasal GangliaElectrocorticographyHumansPhysical Therapy ModalitiesCortical gamma oscillationsDeep brain stimulationParkinson's diseaseSub-harmonic entrainmentWilson-Cowan model

Identifiers

PMID37683763
PMCPMC10635843
OpenAlexW4386485246

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.