Evidence map›Paper›PMID 37683670›Full record

Trial reportAmerican journal of perinatology2024

Progression of Enteral Feeding Volumes in Extremely Low Birth Weight Infants in the "Connection Trial".

Josef Neu, Patricia Ashley, Vikas Chowdhary, Andrea Lampland, Peter Porcelli, Robert Rothstein, Boriana Slancheva, Anders Kronström, Jonas Rastad, Staffan Strömberg and 2 more

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of perinatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Josef NeuDepartment of Pediatrics, University of Florida Health Shands Children's Hospital, Gainesville, Florida.
Patricia AshleyDepartment of Pediatrics, Duke University, Durham, North Carolina.
Vikas ChowdharyDepartment of Pediatrics, Arkansas Children's Hospital, Little Rock, Arkansas.
Andrea LamplandDepartment of Neonatology, Children's Minnesota St. Paul Clinic, Saint Paul, Minnesota.
Peter PorcelliDepartment of Pediatrics, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina.
Robert RothsteinDepartment of Pediatrics, Baystate Children's Hospital, Springfield, Massachusetts.
Boriana SlanchevaDepartment of Neonatology, Medical University of Sofia, Sofia, Bulgaria.
Anders KronströmInfant Bacterial Therapeutics Inc., Stockholm, Sweden.
Jonas RastadInfant Bacterial Therapeutics Inc., Stockholm, Sweden.
Staffan StrömbergInfant Bacterial Therapeutics Inc., Stockholm, Sweden.
Marcus ThuressonInfant Bacterial Therapeutics Inc., Stockholm, Sweden.
Connection Study Group
Arkansas Children's Hospital · USAtrium Health Wake Forest Baptist · USBaystate Medical Center · USChildren’s Minnesota - St. Paul Hospital · USDuke University · USMedical University of Sofia · BGUniversity of Florida Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveInvestigate daily feeding volumes and their association with clinical variables in the early postnatal care of premature infants of the "Connection Trial." STUDY

designA total of 641 infants of 510 to 1,000-g birth weight (BW, mean: 847 g) and mean 27 weeks' gestational age at birth (GA) were analyzed for total daily enteral (TDE) feeding volumes of 10, 20, 40, 80, and 120 mL/kg/d and their association with 24 clinical variables. Uni- and multivariable Cox regression models were used to calculate hazard ratios (HR) with 95% confidence intervals as a measure of the chance of reaching each of the TDE volumes.

resultsDaily feeding volumes were highly variable and the median advancement from 10 to 120 mL/kg/d was 11 mL/kg/d. Univariable analyses showed the lowest chance (HR, 0.22-0.81) of reaching the TDE volumes for gastrointestinal (GI) serious adverse events (SAEs), GI perforation, GI obstruction, and necrotizing enterocolitis, as well as respiratory SAEs, persistent ductus arteriosus, and hypotension. Each GA week, 100-g BW, and point in 5-minute Apgar score at birth associated with 8 to 20% increased chance of reaching the TDE volumes. Multivariable analyses showed independent effects for BW, GA, Apgar score, GI SAEs, abdominal symptoms/signs, respiratory SAEs, days on antibiotics, and hypotension.

conclusionThis observational analysis demonstrates the variable and cautious progression of enteral feedings in contemporary extremely low BW infants and the extent to which clinical variables associate with this progression. KEY POINTS: · Total feedings of 10 and 120 mL/kg/d were reached at median 4 and 14 day of age, respectively, and at a daily increase of 11 mL/kg.. · Each incremental GA week, 100-g BW, and point in 5-minute Apgar score associated with 8 to 20% increased chance of reaching enteral feedings of 10 to 120 mL/kg/d.. · Progression of enteral feeding associated with several clinical events and was slower than advocated in common feeding protocols..

Indexed as

Enteral NutritionGestational AgeInfant, Extremely Low Birth WeightEnterocolitis, NecrotizingFemaleHumansInfant, NewbornInfant, PrematureMaleMultivariate AnalysisProportional Hazards Models

Identifiers

PMID37683670
PMCPMC11663079
OpenAlexW4386533868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.