Evidence map›Paper›PMID 37683659›Full record

ArticleRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2023

Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region.

Luís Felipe Leite Martins, Miguel Ângelo Martins Moreira, Rodrigo Alves Pinto, Neilane Bertoni Dos Reis, Shayany Pinto Felix, João Paulo Castello Branco Vidal, Leuridan Cavalcante Torres, Ariani Impieri Souza, Liz Maria de Almeida

Open access · diamondAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Luís Felipe Leite MartinsCancer Surveillance and Data Analysis Division, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil.ORCID 0000-0001-5016-8459
Miguel Ângelo Martins MoreiraTumor Genetics and Virology Program, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil.ORCID 0000-0003-1437-7522
Rodrigo Alves PintoInstituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brazil.ORCID 0000-0003-0492-7316
Neilane Bertoni Dos ReisDivision of Population Research, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil.ORCID 0000-0002-2539-9965
Shayany Pinto FelixTumor Genetics and Virology Program, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil.ORCID 0000-0003-2209-8961
João Paulo Castello Branco VidalUniversidade Federal do Maranhão, São Luis, MA, Brazil.ORCID 0000-0002-2984-8131
Leuridan Cavalcante TorresInstituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brazil.ORCID 0000-0003-3517-6615
Ariani Impieri SouzaInstituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brazil.ORCID 0000-0002-7917-5983
Liz Maria de AlmeidaCoordination of Prevention and Surveillance, Instituto Nacional do Câncer, Rio de Janeiro, RJ, Brazil.ORCID 0000-0002-2359-0651
Instituto Nacional de Câncer - INCA · BRInstituto de Medicina Integral Professor Fernando Figueira · BRUniversidade Federal do Maranhão · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSimilar to Human Papillomavirus (HPV) genotypes, different lineages of a genotype also have different carcinogenic capabilities. Studies have shown that specific genotype lineages of oncogenic HPV are associated with variable risks for the development of cervical intraepithelial neoplasia (CIN2/CIN3) and cervical cancer. The present study aimed to analyze the genetic diversity of the HPV16 genotype in women with CIN2/CIN3 and cervical cancer, from the northeast region of Brazil.

methodsA cross-sectional multicenter study was conducted in the northeast region of Brazil, from 2014 to 2016. This study included 196 cases of HPV16 variants (59 and 137 cases of CIN2/CIN3 and cervical cancer, respectively). The difference of proportion test was used to compare patients with CIN2/CIN3 and cervical cancer, based on the prevalent HPV16 lineage (

resultsAccording to the histopathological diagnosis, the percentage of lineage frequencies revealed a marginal difference in the prevalence of lineage A in CIN2/CIN3, compared with that in cervical cancer (

conclusionHPV16 lineage A was the most frequent lineage in both CIN2/CIN3 and cervical cancer samples, while lineage D was predominant in cervical cancer, suggesting a possible association between HPV16 lineage D and cervical cancer.

Indexed as

Papillomavirus InfectionsUterine Cervical NeoplasmsBrazilCross-Sectional StudiesFemaleHuman papillomavirus 16Human Papillomavirus VirusesHumansPapillomaviridae

Identifiers

PMID37683659
PMCPMC10491469
OpenAlexW4386534142

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.