Evidence map›Paper›PMID 37683509›Full record

ArticleSchizophrenia research2023

Associations of comorbid substance use disorders with clinical outcomes in schizophrenia using electronic health record data.

Rashmi Patel, Kelly M Y Chan, Emily O C Palmer, Matthew Valko, Guruprabha Guruswamy, Sheryl Ker, Gunjan Batra, Miguel E Rentería, Scott H Kollins

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rashmi PatelKing's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK. Electronic address: rashmi.patel@kcl.ac.uk.
Kelly M Y ChanHolmusk Technologies Inc., New York, NY, USA.
Emily O C PalmerHolmusk Technologies Inc., New York, NY, USA.
Matthew ValkoHolmusk Technologies Inc., New York, NY, USA.
Guruprabha GuruswamyHolmusk Technologies Inc., New York, NY, USA.
Sheryl KerHolmusk Technologies Inc., New York, NY, USA.
Gunjan BatraHolmusk Technologies Inc., New York, NY, USA.
Miguel E RenteríaHolmusk Technologies Inc., New York, NY, USA.
Scott H KollinsHolmusk Technologies Inc., New York, NY, USA.
King's College London · GB

Funding

Department of Health NIHR301690Medical Research Council MR/S003118/1
6 · The paper itself

Abstract

background and hypothesisSchizophrenia and comorbid substance use disorders (SUDs) are associated with poor treatment outcomes but differences between the associations of different SUDs with clinical outcomes are poorly characterized. This study examines the associations of comorbid SUDs with clinical outcomes in schizophrenia using a largescale electronic health record (EHR) database.

designReal-world data (RWD) analysis using the NeuroBlu database; de-identified EHR data were analysed. Multivariable logistic regression, Poisson and CoxPH models were used to compare the associations of specific comorbid SUDs with outcome variables.

resultsComorbid SUD was significantly different on all outcome measures compared to no SUD (U = 1.44e

conclusionComorbid SUDs were generally associated with greater CGI-S and poorer clinical outcomes in patients with schizophrenia. Treatment strategies should target not only schizophrenia symptoms but also comorbid SUD to improve management of both conditions.

Indexed as

Antipsychotic AgentsCannabisCocaineCocaine-Related DisordersSchizophreniaSubstance-Related DisordersComorbidityElectronic Health RecordsHumansAntipsychotic AgentsCocaineHospital utilizationIllness severityNeuroBluReal-world evidenceTreatment discontinuationTreatment patterns

Identifiers

PMID37683509
PMCPMC10881404
OpenAlexW4386564532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.