Evidence map›Paper›PMID 37683506›Full record

ArticleEnvironment international2023

Long-term exposure to summer specific humidity and cardiovascular disease hospitalizations in the US Medicare population.

Jochem O Klompmaker, Francine Laden, Peter James, M Benjamin Sabath, Xiao Wu, Francesca Dominici, Antonella Zanobetti, Jaime E Hart

Open access · goldAbstract read
In one paragraph

Article in Environment international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. [Environmental relative humidity, frailty, and risk of incident stroke among middle-aged and older adults in China: A prospective cohort study].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
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  13. Association between low-concentration PMFrontiers in public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jochem O KlompmakerDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: jklompmaker@hsph.harvard.edu.
Francine LadenDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Peter JamesDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.
M Benjamin SabathDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Xiao WuDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Francesca DominiciDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Antonella ZanobettiDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Jaime E HartDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Harvard University · USBrigham and Women's Hospital · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
National Cohort Studies of Alzheimer's Disease, Related Dementias and Air PollutionR01AG066793 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ZANOBETTI, ANTONELLA · 2020 to 2025
$4.2M
Built Environment Assessment through Computer visiON (BEACON): Applying Deep Learning to Street-Level and Satellite Images to Estimate Built Environment Effects on Cardiovascular HealthR01HL150119 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JAMES, PETER · 2020 to 2024
$3.9M
Environmental Health Disparities in an Older PopulationR01MD012769 · NIMHD · YALE UNIVERSITY · PI BELL, MICHELLE L · 2017 to 2021
$3.9M
Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and SusceptibilityR01ES028033 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DOMINICI, FRANCESCA, LADEN, FRANCINE · 2018 to 2022
$3.5M
Integrating Air Pollution Prediction Models: Uncertainty Quantification and Propagation in Health StudiesR01ES030616 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DOMINICI, FRANCESCA, KIOUMOURTZOGLOU, MARIANTHI-ANNA · 2020 to 2024
$3.1M
Disease Outcomes iN Older adults under extreme Heat, AiR pollution and Medication use (DO-NO-HARM)R01AG060232 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI SETOGUCHI IWATA, SOKO · 2019 to 2023
$3.0M
The confluence of extreme heat cold on the health and longevity of an Aging Population with Alzheimers and related DementiaRF1AG074372 · NIA · HARVARD MEDICAL SCHOOL · PI DOMINICI, FRANCESCA, ESTIRI, HOSSEIN · 2022 to 2023
$2.6M
Cardiovascular Health and Air Pollution: A National StudyR01ES024332 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI ZANOBETTI, ANTONELLA · 2015 to 2018
$2.5M
Evidence to improve heat warning effectiveness in reducing morbidity and mortality.R01ES029950 · NIEHS · BROWN UNIVERSITY · PI WELLENIUS, GREGORY A · 2019 to 2022
$2.5M
Short and long-term consequences of wildfires for Alzheimer's disease and related dementias.RF1AG071024 · NIA · UNIVERSITY OF WASHINGTON · PI CASEY, JOAN A · 2021 to 2022
$2.4M
NHLBI NIH HHS R01 HL150119NIA NIH HHS R01 AG060232NIA NIH HHS R01 AG066793NIA NIH HHS RF1 AG071024NIA NIH HHS RF1 AG074372NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES024332NIEHS NIH HHS R01 ES026217NIEHS NIH HHS R01 ES028033NIEHS NIH HHS R01 ES029950NIEHS NIH HHS R01 ES030616NIEHS NIH HHS T32 ES007069NIMHD NIH HHS R01 MD012769
6 · The paper itself

Abstract

introductionMost climate-health studies focus on temperature; however, less is known about health effects of exposure to atmospheric moisture. Humid air limits sweat evaporation from the body and can in turn exert strain on the cardiovascular system. We evaluated associations of long-term exposure to summer specific humidity with cardiovascular disease (CVD), coronary heart disease (CHD) and cerebrovascular disease (CBV) hospitalization.

methodsWe built an open cohort consisting of ∼63 million fee-for-service Medicare beneficiaries, aged ≥65, living in the contiguous US (2000-2016). We assessed zip code level summer average specific humidity and specific humidity variability, based on daily estimates from the Gridded Surface Meteorological dataset (∼4km spatial resolution). To estimate associations of summer specific humidity with first CVD, CHD, and CBV hospitalization, we used Cox-equivalent Poisson models adjusted for individual and area-level socioeconomic status indicators, temperature, and winter specific humidity.

resultsHigher summer average specific humidity was associated with an increased risk of CVD, CHD, and CBV hospitalization. We found hazard ratios (HRs) of 1.07 (95%CI: 1.07, 1.08) for CVD hospitalization, 1.08 (95%CI: 1.08, 1.09) for CHD hospitalization, and 1.07 (95%CI: 1.07, 1.08) for CBV hospitalization per IQR increase (4.0 g of water vapor/kg of dry air) in summer average specific humidity. Associations of summer average specific humidity were strongest for beneficiaries eligible for Medicaid and for beneficiaries with an unknown or other race. Higher summer specific humidity variability was also associated with increased risk of CVD, CHD, and CBV hospitalization. Associations were not affected by adjustment for temperature and regions of the US, as well as exclusion of potentially prevalent cases.

conclusionLong-term exposure to higher summer average specific humidity and specific humidity variability were positively associated with CVD hospitalization. As global warming could increase humidity levels, our findings are important to assess potential health impacts of climate change.

Indexed as

Cardiovascular DiseasesAgedClimate ChangeHospitalizationHumansHumidityMedicareUnited StatesCardiovascular diseaseClimateHumidityMoisture

Identifiers

PMID37683506
PMCPMC10545022
OpenAlexW4386400969

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.