Evidence map›Paper›PMID 37682870›Full record

SynthesisThe Journal of infectious diseases2024

Cytomegalovirus Viral Load Threshold to Guide Preemptive Therapy in Hematopoietic Cell Transplant Recipients: Correlation With Cytomegalovirus Disease.

Alicja Sadowska-Klasa, Wendy M Leisenring, Ajit P Limaye, Michael Boeckh

Abstract readSystematic Review
In one paragraph

Synthesis in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Case Report: Pulmonary mixed infection byFrontiers in immunology · 2025
    Article
  11. Review
  12. Article
  13. Understanding the Clinical Significance of Cytomegalovirus Viremia After Chimeric Antigen Receptor T-Cell Therapy: Should We be Treating a Value?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alicja Sadowska-KlasaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Wendy M LeisenringVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Ajit P LimayeVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0002-5350-9025
Michael BoeckhVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Funding

1/2 Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients with Acute Respiratory Failure and SepsisUH3HL147011 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BOECKH, MICHAEL J, LIMAYE, ABHIJIT PRAKASH · 2021 to 2024
$8.7M
1/2 Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients with Acute Respiratory Failure and SepsisUG3HL147011 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BOECKH, MICHAEL J, LIMAYE, ABHIJIT PRAKASH · 2020 to 2020
$2.3M
CenterFred Hutchinson CancerMeyers Scholarship EndowmentNHLBI NIH HHS UG3 HL147011NHLBI NIH HHS UH3 HL147011NIH HHS HHSN272201600015CPolish National Agency for Academic Exchange
6 · The paper itself

Abstract

A systematic review of randomized and observational studies from 2013 to 2023 demonstrated that antiviral preemptive therapy started at cytomegalovirus viral load thresholds between 2 and 3 log10 IU/mL was associated with similar cytomegalovirus disease rates. Thus, viral thresholds in this range appear to effectively protect patients not receiving prophylaxis.

Indexed as

Antiviral AgentsCytomegalovirusCytomegalovirus InfectionsHematopoietic Stem Cell TransplantationViral LoadHumansObservational Studies as TopicRandomized Controlled Trials as TopicTransplant RecipientsAntiviral AgentsCMVCMV diseasepreemptive therapyreviewviral load threshold

Identifiers

PMID37682870
PMCPMC11095528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.