Evidence map›Paper›PMID 37682510›Full record

ArticleApplied biochemistry and biotechnology2024

Sustainable Nanoparticles from Stephania glabra and Analysis of Their Anticancer Potential on 2D and 3D Models of Prostate Cancer.

Prachi Vaid, Adesh K Saini, Raju Kumar Gupta, Eshu Singhal Sinha, Deepak Sharma, Walaa F Alsanie, Vijay Kumar Thakur, Reena V Saini

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Article in Applied biochemistry and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Prachi VaidSchool of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, 173229, H, Solan, .P, India.
Adesh K SainiCentral Research Laboratory and Department of Bio-sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India.
Raju Kumar GuptaDepartment of Chemical Engineering, Indian Institute of Technology Kanpur, U, Kanpur, .P, India.
Eshu Singhal SinhaDepartment of Biotechnology, Panjab University, Chandigarh, 160014, India.
Deepak SharmaCSIR-Institute of Microbial Technology, Chandigarh, 160036, India.
Walaa F AlsanieDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Vijay Kumar ThakurBiorefining and Advanced Materials Research Centre, Scotland's Rural College (SRUC), Kings Buildings, Edinburgh, EH9 3JG, UK.
Reena V SainiCentral Research Laboratory and Department of Bio-sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, 133207, India. reenavohra10@gmail.com.ORCID http://orcid.org/0000-0002-8163-5790

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In pursuit of a novel effective treatment for prostate cancer, methanolic extract of Stephania glabra tubers (Sg-ME) was utilized to fabricate silver (Sg-AgNP), copper oxide (Sg-CuONP), and silver-copper bimetallic nanoparticles (Sg-BNP). The characterization of the nanoparticles confirmed spherical shape with average diameters of 30.72, 32.19, and 25.59 nm of Sg-AgNP, Sg-CuONP, and Sg-BNP, respectively. Interestingly, these nanoparticles exhibited significant cytotoxicity toward the prostate cancer (PC3) cell line while being non-toxic toward normal cells. The nanoparticles were capable of inducing apoptosis in PC3 cells by enhancing reactive oxygen species (ROS) generation and mitochondrial depolarization. Furthermore, the shrinkage of 3D prostate tumor spheroids was observed after 4 days of treatment with these green nanoparticles. The 3D model system was less susceptible to nanoparticles as compared to the 2D model system. Sg-BNP showed the highest anticancer potential on 2D and 3D prostate cancer models.

Indexed as

Antineoplastic AgentsMetal NanoparticlesProstatic NeoplasmsSilverApoptosisCell Line, TumorCopperHumansMalePC-3 CellsPlant ExtractsReactive Oxygen SpeciesAntineoplastic AgentsCopperPlant ExtractsReactive Oxygen SpeciesSilver3D tumor modelApoptosisBimetallic nanoparticlesCopper oxide nanoparticlesProstate cancerSilver nanoparticlesStephania glabra

Identifiers

PMID37682510

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.