Evidence map›Paper›PMID 37682311›Full record

ArticleCellular and molecular life sciences : CMLS2023

The proper interplay between the expression of Spo11 splice isoforms and the structure of the pseudoautosomal region promotes XY chromosomes recombination.

Teresa Giannattasio, Erika Testa, Monica Faieta, Matteo Lampitto, Daniela Nardozi, Stefano di Cecca, Antonella Russo, Marco Barchi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Controlling Meiotic Double-Strand Break Formation in Mice: A Web of Multivalent Protein-Protein Interactions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Article
  3. Reconstitution of SPO11-dependent double-strand break formation.bioRxiv : the preprint server for biology · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Teresa GiannattasioDepartment of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy.ORCID http://orcid.org/0009-0008-5234-3546
Erika TestaDepartment of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy.
Monica FaietaDepartment of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy.
Matteo LampittoDepartment of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy.
Daniela NardoziDepartment of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy.
Stefano di CeccaDepartment of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy.
Antonella RussoDepartment of Molecular Medicine, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0001-6691-257X
Marco BarchiDepartment of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy. marco.barchi@uniroma2.it.ORCID http://orcid.org/0000-0003-1104-6234
University of Rome Tor Vergata · ITUniversity of Padua · IT

Funding

Fondazione Telethon GGP12189Intesa Sanpaolo Innovation Center B/2021/0228Regione Lazio A0375-2020-36618Università degli Studi di Roma Tor Vergata 141
6 · The paper itself

Abstract

XY chromosome missegregation is relatively common in humans and can lead to sterility or the generation of aneuploid spermatozoa. A leading cause of XY missegregation in mammals is the lack of formation of double-strand breaks (DSBs) in the pseudoautosomal region (PAR), a defect that may occur in mice due to faulty expression of Spo11 splice isoforms. Using a knock-in (ki) mouse that expresses only the single Spo11β splice isoform, here we demonstrate that by varying the genetic background of mice, the length of chromatin loops extending from the PAR axis and the XY recombination proficiency varies. In spermatocytes of C57

Indexed as

EndodeoxyribonucleasesPseudoautosomal RegionsAllelesAnimalsHumansMaleMeiotic Recombination Protein SPO11MiceProtein IsoformsRecombination, GeneticSemenEndodeoxyribonucleasesMeiotic Recombination Protein SPO11Protein IsoformsAneuploidyChromosome structureDouble strand breaksMeiosisMeiotic recombinationPARSex chromosomesSplicingSPO11αSPO11β

Identifiers

PMID37682311
PMCPMC10491539
OpenAlexW4386531077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.