Evidence map›Paper›PMID 37682286›Full record

SynthesisWorld journal of urology2023

What to expect from the novel pulsed thulium:YAG laser? A systematic review of endourological applications.

Eugenio Ventimiglia, Daniele Robesti, Luigi Bevilacqua, Elena Tondelli, Isabella Oliva, Luca Orecchia, Patrick Juliebø-Jones, Amelia Pietropaolo, Vincent De Coninck, Francesco Esperto and 9 more

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06721975 (Prospective Single-center Study Comparing Thulium Fiber Laser to Pulsed Thulium), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06721975 narecruitingnot on this mapstarted 2024, after this paper: background citation

Prospective Single-center Study Comparing Thulium Fiber Laser to Pulsed Thulium:YAG Laser in the Ureteroscopic Treatment of Nephrolithiasis

TypeinterventionalSponsorUniversity of California, San DiegoRan2024 to 2026Enrolled50ConditionsKidney Stones, NephrolithiasisArmsThulio pulsed Thulium:YAG (p-Tm:YAG), Thulium Laser Fiber (TFL)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  13. Retrospective study of ureteral stenosis after holmium laser lithotripsy.The Journal of international medical research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Eugenio VentimigliaDivision of Experimental Oncology/Unit of Urology, URI-Urological Research Institute, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Via Olgettina 60, 20132, Milan, Italy. eugenio.ventimiglia@gmail.com.ORCID http://orcid.org/0000-0003-3654-1629
Daniele RobestiDivision of Experimental Oncology/Unit of Urology, URI-Urological Research Institute, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Via Olgettina 60, 20132, Milan, Italy.
Luigi BevilacquaDepartment of Urology, Istituto Clinico Beato Matteo, Vigevano, Italy.
Elena TondelliDepartment of Urology, Istituto Clinico Beato Matteo, Vigevano, Italy.
Isabella OlivaDepartment of Urology, Istituto Clinico Beato Matteo, Vigevano, Italy.
Luca OrecchiaDepartment of Urology, Istituto Clinico Beato Matteo, Vigevano, Italy.
Patrick Juliebø-JonesYoung Academic Urologists (YAU), Urolithiasis and Endourology Working Party, Arnhem, The Netherlands.
Amelia PietropaoloYoung Academic Urologists (YAU), Urolithiasis and Endourology Working Party, Arnhem, The Netherlands.
Vincent De ConinckYoung Academic Urologists (YAU), Urolithiasis and Endourology Working Party, Arnhem, The Netherlands.
Francesco EspertoYoung Academic Urologists (YAU), Urolithiasis and Endourology Working Party, Arnhem, The Netherlands.
Thomas TaillyDepartment of Urology, University Hospital Ghent, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
Stefania FerrettiUrology Department, Hospital and University of Modena, Modena, Italy.
Vineet GauharDepartment of Urology, Ng Teng Fong General Hospital, Singapore, Singapore.
Bhaskar SomaniDepartment of Urology, University Hospitals Southampton, NHS Trust, Southampton, UK.
Luca VillaDivision of Experimental Oncology/Unit of Urology, URI-Urological Research Institute, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Via Olgettina 60, 20132, Milan, Italy.
Etienne Xavier KellerYoung Academic Urologists (YAU), Urolithiasis and Endourology Working Party, Arnhem, The Netherlands.
Andrea SaloniaDivision of Experimental Oncology/Unit of Urology, URI-Urological Research Institute, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Via Olgettina 60, 20132, Milan, Italy.
Olivier TraxerSorbonne Universite, 27063, GRC#20 Lithiase Urinaire, Hôpital Tenon, Paris, Île-de-France, France.
Ioannis Kartalas GoumasProgressive Endourological Association for Research and Leading Solutions (PEARLS), Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSeveral preclinical studies about a novel pulsed-thulium:yttrium-aluminum-garnet (p-Tm:YAG) device have been published, demonstrating its possible clinical relevance.

methodsWe systematically reviewed the reality and expectations for this new p-Tm:YAG technology. A PubMed, Scopus and Embase search were performed. All relevant studies and data identified in the bibliographic search were selected, categorized, and summarized.

resultsTm:YAG is a solid state diode-pumped laser that emits at a wavelength of 2013 nm, in the infrared spectrum. Despite being close to the Ho:YAG emission wavelength (2120 nm), Tm:YAG is much closer to the water absorption peak and has higher absorption coefficient in liquid water. At present, there very few evaluations of the commercially available p-Tm:YAG devices. There is a lack of information on how the technical aspects, functionality and pulse mechanism can be maximized for clinical utility. Available preclinical studies suggest that p-Tm:YAG laser may potentially increase the ablated stone weight as compared to Ho:YAG under specific condition and similar laser parameters, showing lower retropulsion as well. Regarding laser safety, a preclinical study observed similar absolute temperature and cumulative equivalent minutes at 43° C as compared to Ho:YAG. Finally, laser-associated soft-tissue damage was assessed at histological level, showing similar extent of alterations due to coagulation and necrosis when compared with the other clinically relevant lasers.

conclusionsThe p-Tm:YAG appears to be a potential alternative to the Ho:YAG and TFL according to these preliminary laboratory data. Due to its novelty, further studies are needed to broaden our understanding of its functioning and clinical applicability.

Indexed as

Lasers, Solid-StateLithotripsy, LaserHolmiumHumansTemperatureThuliumWaterHolmiumThuliumWaterHolmium:YAGLaserLithotripsyTFLThulium:YAG

Identifiers

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.