Evidence map›Paper›PMID 37682237›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Accelerated atherosclerosis in beta-thalassemia.

Julian Hurtado, Hassan Sellak, Giji Joseph, Caitlin V Lewis, Crystal R Naudin, Sergio Garcia, James Robert Wodicka, David R Archer, W Robert Taylor

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Julian HurtadoDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.ORCID 0000-0003-0404-2673
Hassan SellakDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
Giji JosephDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
Caitlin V LewisDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
Crystal R NaudinDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.ORCID 0000-0001-6171-2640
Sergio GarciaDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
James Robert WodickaDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.ORCID 0000-0003-2139-2536
David R ArcherAflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta and the Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States.
W Robert TaylorDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.ORCID 0000-0002-5765-2419
Emory University · USGeorgia Institute of Technology · US

Funding

Research Trainng in Academic CardiologyT32HL007745 · NHLBI · EMORY UNIVERSITY · PI TAYLOR, WILLIAM ROBERT · 1994 to 2023
$10.6M
INTEGRATED TRAINING IN ANESTHESIOLOGY RESEARCHT32GM008600 · NIGMS · DUKE UNIVERSITY · PI Miriam Treggiari · 1996 to 2026
$6.6M
Impaired Collateral Vessel Formation in Sickle Cell DiseaseR01HL131414 · NHLBI · EMORY UNIVERSITY · PI ARCHER, DAVID R, TAYLOR, WILLIAM ROBERT · 2016 to 2019
$2.4M
NHLBI NIH HHS R01 HL131414NHLBI NIH HHS T32 HL007745NIGMS NIH HHS T32 GM008600
6 · The paper itself

Abstract

Children with beta-thalassemia (BT) present with an increase in carotid intima-medial thickness, an early sign suggestive of premature atherosclerosis. However, it is unknown if there is a direct relationship between BT and atherosclerotic disease. To evaluate this, wild-type (WT, littermates) and BT (Hbb

Indexed as

Aortic DiseasesAtherosclerosisbeta-ThalassemiaPlaque, AtheroscleroticAnimalsChildDeferiproneFemaleHemeHemolysisHemopexinHumansIron Chelating AgentsMaleMiceMice, Inbred C57BLDeferiproneHemeHemopexinIron Chelating AgentsPCSK9 protein, humanPhenylhydrazinesProprotein Convertase 9atherosclerosisbeta-thalassemia

Identifiers

PMID37682237
PMCPMC10908407
OpenAlexW4386529497

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.