Trial reportAmerican journal of physiology. Heart and circulatory physiology2023
Time-efficient, high-resistance inspiratory muscle strength training increases cerebrovascular reactivity in midlife and older adults.
Trial report in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Inspiratory muscle training and cardiac autonomic function in healthy adults: a systematic review of acute and chronic responses.Frontiers in cardiovascular medicine · 2026Pooled it
- Effect of Inspiratory Muscle Training on Diaphragm and Abdominal Wall Muscle Thickness with Fatty Liver Density in Elderly Women: A Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2025Trial
- Short-Term Inspiratory Muscle Training Enhances Functional and Metabolic Health in Older Adults.Healthcare (Basel, Switzerland) · 2026Article
- The effectiveness of respiratory training as a preventive strategy against cognitive decline: a mini review.Frontiers in rehabilitation sciences · 2026Review
- An exaggerated blood pressure response to exercise is associated with attenuated exercise-induced acute cognitive improvement: A pilot study.Physiological reports · 2025Article
- The effectiveness of functional inspiratory muscle training on exercise capacity and peripheral muscle strength in patients with essential hypertension: a three-arm randomized controlled trial.BMC sports science, medicine & rehabilitation · 2025Article
- Oxidative stress suppresses internal carotid artery dilation to hypercapnia in healthy older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- High-resistance inspiratory muscle strength training: a promising strategy for improving vascular health in chronic kidney disease.Frontiers in physiology · 2025Article
- Article
- Declining nitric oxide bioavailability in cardiovascular aging: mechanistic insights and emerging interventions.The journal of cardiovascular aging · 2025Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Aging is associated with increased risk for cognitive decline and dementia due in part to increases in systolic blood pressure (SBP) and cerebrovascular dysfunction. High-resistance inspiratory muscle strength training (IMST) is a time-efficient, intensive respiratory training protocol (30 resisted inspirations/day) that lowers SBP and improves peripheral vascular function in midlife/older adults with above-normal SBP. However, whether, and by what mechanisms, IMST can improve cerebrovascular function is unknown. We hypothesized that IMST would increase cerebrovascular reactivity to hypercapnia (CVR to CO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.