Evidence map›Paper›PMID 37681986›Full record

ArticleMicrobiology spectrum2023

Blocking ADP-ribosylation expands the anti-mycobacterial spectrum of rifamycins.

Uday S Ganapathy, Tian Lan, Véronique Dartois, Courtney C Aldrich, Thomas Dick

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Next-generation rifamycins for the treatment of mycobacterial infections.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Exploring antibiotic resistance mechanisms inFrontiers in microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Uday S Ganapathy *Center for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.
Tian Lan *Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota, USA.
Véronique DartoisCenter for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.
Courtney C AldrichDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota, USA.
Thomas DickCenter for Discovery and Innovation, Hackensack Meridian Health , Nutley, New Jersey, USA.ORCID 0000-0002-9604-9452
Hackensack Meridian Health · USUniversity of Minnesota · USGeorgetown University · US

Funding

Therapeutics for drug-resistant bacteria: aryl myxopyronins and arylalkylcarboxamido phloroglucinolsU19AI142731 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI EBRIGHT, RICHARD H. · 2019 to 2023
$33.9M
Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung diseaseR01AI132374 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI Thomas Dick · 2018 to 2026
$7.0M
Optimization of rifamycins to overcome intrinsic resistance of nontuberculous mycobacteria to improve treatment of NTM lung diseaseR01AI177342 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI Courtney Cortez Aldrich, Thomas Dick · 2023 to 2026
$3.4M
HHS | National Institutes of Health (NIH) R01AI132374HHS | National Institutes of Health (NIH) U19AI142731NIAID NIH HHS R01 AI132374NIAID NIH HHS R01 AI177342NIAID NIH HHS U19 AI142731
6 · The paper itself

Abstract

importanceLung disease caused by a range of different species of non-tuberculous mycobacteria (NTM) is difficult to cure. The rifamycins are very active against

Indexed as

ADP-ribosylationM. abscessusM. chelonaeM. fortuitumM. simiaeM. xenopinon-tuberculous mycobacteriaNTMrifamycins

Identifiers

PMID37681986
PMCPMC10580999
OpenAlexW4386529457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.