Evidence map›Paper›PMID 37681977›Full record

ArticleAntimicrobial agents and chemotherapy2023

An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from

Romain Aubry, Julien Buyck, Laure Prouvensier, Jean-Winoc Decousser, Patrice Nordmann, Sebastian G Wicha, Sandrine Marchand, Nicolas Grégoire

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Romain AubryUniversité de Poitiers, PHAR2, Inserm U1070 , Poitiers, France.
Julien BuyckUniversité de Poitiers, PHAR2, Inserm U1070 , Poitiers, France.ORCID 0000-0003-0299-4654
Laure ProuvensierUniversité de Poitiers, PHAR2, Inserm U1070 , Poitiers, France.
Jean-Winoc DecousserDepartment of Bacteriology and Infection Control, University Hospital Henri Mondor, Assistance Publique - Hôpitaux de Paris , Créteil, France.
Patrice NordmannMedical and Molecular Microbiology Unit, Faculty of Science and Medicine, University of Fribourg , Fribourg, Switzerland.
Sebastian G WichaDepartment of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg , Hamburg, Germany.
Sandrine MarchandUniversité de Poitiers, PHAR2, Inserm U1070 , Poitiers, France.
Nicolas GrégoireUniversité de Poitiers, PHAR2, Inserm U1070 , Poitiers, France.ORCID 0000-0001-6436-3757
Inserm · FRÉcole Nationale Vétérinaire d'Alfort · FRUniversität Hamburg · DEUniversity of Fribourg · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In contrast to the checkerboard method, bactericidal experiments [time-kill curves (TKCs)] allow an assessment of pharmacodynamic (PD) interactions over time. However, TKCs in combination pose interpretation problems. The objective of this study was to characterize the PD interaction over time between ceftazidime/avibactam (CZA) and colistin (CST) using TKC against four multidrug-resistant

Indexed as

CeftazidimeKlebsiella InfectionsAnti-Bacterial AgentsAzabicyclo Compoundsbeta-LactamasesColistinDrug CombinationsHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsAnti-Bacterial AgentsavibactamAzabicyclo Compoundsbeta-LactamasesCeftazidimeColistinDrug Combinationsantimicrobial combinationceftazidime/avibactamcolistinPKPD modeling

Identifiers

PMID37681977
PMCPMC10583682
OpenAlexW4386531235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.