Evidence map›Paper›PMID 37681969›Full record

ArticleAntimicrobial agents and chemotherapy2023

A small-molecule membrane fluidizer re-sensitizes methicillin-resistant

Jessica D Podoll, Emma Rosen, Wei Wang, Yuefeng Gao, Jing Zhang, Xiang Wang

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jessica D PodollRecreo Pharmaceuticals Inc, Yale Circle , Boulder, Colorado, USA.
Emma RosenRecreo Pharmaceuticals Inc, Yale Circle , Boulder, Colorado, USA.
Wei WangDepartment of Chemistry, University of Colorado , Boulder, Colorado, USA.
Yuefeng GaoDepartment of Chemistry, University of Colorado , Boulder, Colorado, USA.
Jing ZhangRecreo Pharmaceuticals Inc, Yale Circle , Boulder, Colorado, USA.
Xiang WangDepartment of Chemistry, University of Colorado , Boulder, Colorado, USA.ORCID 0000-0003-0396-7404

Funding

Development of Novel Resistance-Modifying Agents for MRSAR33AI121581 · NIAID · UNIVERSITY OF COLORADO · PI WANG, XIANG · 2018 to 2020
$1.4M
NIAID NIH HHS R33 AI121581
6 · The paper itself

Abstract

Novel antibacterial agents and strategies are urgently needed to fight against the ongoing global antibiotic resistance problem. While natural products remain the main source in antibiotic discovery, synthetic antibacterials provide an attractive alternative and may evade the ancient antibiotic resistance. Herein, we report a small molecule that re-sensitizes methicillin-resistant

Indexed as

Methicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsDrug Resistance, MicrobialMicrobial Sensitivity TestsMonobactamsAnti-Bacterial AgentsMonobactamsantibioticantibiotic adjuvantantimicrobial resistancemembrane fluidizer

Identifiers

PMID37681969
PMCPMC10583677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.