Evidence map›Paper›PMID 37681959›Full record

ArticleJournal of virology2023

Epstein-Barr virus-encoded miR-BART11-3p modulates the DUSP6-MAPK axis to promote gastric cancer cell proliferation and metastasis.

Mingqian Xu, Jiarui Lin, Shuaibing Yang, Jiahu Yao, Meiyang Chen, Jinfu Feng, Liang Zhang, Li Zhou, Junjie Zhang, Qingsong Qin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Mingqian XuLaboratory of Human Virology and Oncology, Shantou University Medical College , Shantou, Guangdong Province, China.
Jiarui LinDepartment of Gastrointestinal Surgery, Cancer Hospital of Shantou University Medical College , Shantou, Guangdong, China.
Shuaibing YangLaboratory of Human Virology and Oncology, Shantou University Medical College , Shantou, Guangdong Province, China.
Jiahu YaoLaboratory of Human Virology and Oncology, Shantou University Medical College , Shantou, Guangdong Province, China.
Meiyang ChenLaboratory of Human Virology and Oncology, Shantou University Medical College , Shantou, Guangdong Province, China.
Jinfu FengLaboratory of Human Virology and Oncology, Shantou University Medical College , Shantou, Guangdong Province, China.
Liang ZhangLaboratory of Human Virology and Oncology, Shantou University Medical College , Shantou, Guangdong Province, China.
Li ZhouDepartment of Gynecologic Oncology, Cancer Hospital of Shantou University Medical College , Shantou, China.
Junjie ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, State Key Laboratory of Virology, Medical Research Institute, Wuhan University , Wuhan, China.
Qingsong QinLaboratory of Human Virology and Oncology, Shantou University Medical College , Shantou, Guangdong Province, China.ORCID 0000-0001-6315-5809
Shantou University · CNWuhan University · CN

Funding

Guangdong Science and Technology Department (GDSTC) 200110115871710Guangdong Science and Technology Department (GDSTC) 200114115876753Li Ka Shing Foundation (LKSF) 2020LKSFG13BMOST | National Natural Science Foundation of China (NSFC) 82072292State Key Laboratory of Virology (SKLV) 2022KF010
6 · The paper itself

Abstract

Epstein-Barr virus (EBV)-encoded miRNAs within the BamHI-A rightward transcript (BART) region are abundantly expressed in EBV-associated gastric cancer (EBVaGC), suggesting that they play roles in tumorigenesis. However, how these viral miRNAs contribute to the development of EBVaGC remains largely obscure. In this study, we found that EBV-encoded miR-BART11-3p targets 3' -UTR of dual-specificity phosphatase 6 (DUSP6) mRNA to upregulate ERK phosphorylation and downregulate JNK and p38 phosphorylation. By doing so, miR-BART11-3p promotes gastric cancer (GC) cell proliferation, migration, and invasion

Indexed as

Dual Specificity Phosphatase 6Epstein-Barr Virus InfectionsHerpesvirus 4, HumanMicroRNAsRNA, ViralStomach NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansMAP Kinase Signaling SystemMiceMice, NudeNeoplasm MetastasisDual Specificity Phosphatase 6DUSP6 protein, humanMicroRNAsRNA, Viraldual-specificity phosphatase 6EBV-miR-BART11-3pEpstein-Barr virusgastric cancermitogen-activated protein kinases

Identifiers

PMID37681959
PMCPMC10537804
OpenAlexW4386530137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.