Evidence map›Paper›PMID 37681731›Full record

ArticleThe journal of physical chemistry. B2023

Structure and Dynamics of DNA and RNA Double Helices Formed by d(CTG), d(GTC), r(CUG), and r(GUC) Trinucleotide Repeats and Associated DNA-RNA Hybrids.

Ashkan Fakharzadeh, Jing Qu, Feng Pan, Celeste Sagui, Christopher Roland

Open access · hybridAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ashkan FakharzadehDepartment of Physics, North Carolina State University, Raleigh, North Carolina 27695-8202, USA.
Jing QuDepartment of Physics, North Carolina State University, Raleigh, North Carolina 27695-8202, USA.
Feng PanDepartment of Statistics, Florida State University, Tallahassee, Florida 32306, USA.
Celeste SaguiDepartment of Physics, North Carolina State University, Raleigh, North Carolina 27695-8202, USA.ORCID 0000-0002-2750-5186
Christopher RolandDepartment of Physics, North Carolina State University, Raleigh, North Carolina 27695-8202, USA.
North Carolina State University · USFlorida State University · US

Funding

Trinucleotide Repeats: Atypical Structures, Diseases, and EvolutionR01GM118508 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI SAGUI, MARIA CELESTE · 2016 to 2019
$1.1M
NIGMS NIH HHS R01 GM118508
6 · The paper itself

Abstract

Myotonic dystrophy type 1 is the most frequent form of muscular dystrophy in adults caused by an abnormal expansion of the CTG trinucleotide. Both the expanded DNA and the expanded CUG RNA transcript can fold into hairpins. Co-transcriptional formation of stable RNA·DNA hybrids can also enhance the instability of repeat tracts. We performed molecular dynamics simulations of homoduplexes associated with the disease, d(CTG)

Indexed as

DNATrinucleotide RepeatsAdultBiophysicsHumansHydrogen BondingRNADNARNA

Identifiers

PMID37681731
PMCPMC10519205
OpenAlexW4386530848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.