ArticleUlusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES2023
Elevated HbA1c level associated with disease severity and surgical extension in diabetic foot patients.
Article in Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Self-efficacy, Knowledge and Outcomes Expectations Foot Self-care among Diabetic Patients with High-Risk Feet in Jordan.Current diabetes reviews · 2026Article
- Machine learning-based prediction of major amputation risk after initial limb-preserving surgery in diabetic foot.Frontiers in endocrinology · 2026Article
- Association between triglyceride-glucose (TyG) index and diabetic foot ulcers in adult inpatients with type 2 diabetes at hospital admission.Frontiers in clinical diabetes and healthcare · 2026Article
- Severity of diabetic foot ulcers at various levels of HbA1c.The Pan African medical journal · 2026Article
- Breaking with tradition: perioperative care without fasting or medication changes for diabetic foot surgery.Die Anaesthesiologie · 2025Article
- Prognostic role of HALP score, CRP/albumin ratio and CALLY index in diabetic foot ulcer-related major amputations.Langenbeck's archives of surgery · 2025Article
- Hyperbaric Oxygen Therapy as an Effective Adjunctive Treatment in the Reconstruction of Tissue Defects With Graft in Diabetic Foot Patients: A Retrospective Cohort Study.International wound journal · 2025Article
- Salivary 1,5-Anhydroglucitol and AGEs Are Associated with Postural Instability in Diabetic Foot Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Understanding risk factors and prognosis in diabetic foot ulcers.Open life sciences · 2025Review
- Association of Glycated Hemoglobin Levels with Amputation Outcomes in Patients with Diabetic Foot Ulcers: A Cross-Sectional Study in Southern Iran (2023-2024) : Effect of HbA1c on Diabetic Foot Ulcer Prognosis.Galen medical journal · 2025Article
- Identification of phase angle and Triglyceride-Glucose index as biomarkers for prediction and management of diabetic foot disease.Metabolism open · 2024Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic foot is a complex syndrome that is associated with other diabetic complications, such as peripheral arte-rial disease and peripheral neuropathy. Optimization of plasma glucose and glycated hemoglobin (HbA1c) is one of the main principles of standard care and treatment approaches in individuals with diabetes mellitus (DM). In this study, the relationship of HbA1c level at the time of diagnosis was evaluated with diabetic foot disease severity score and surgical extension in patients with Type 2 DM.
methodsThis study included 301 consecutive patients who were diagnosed with diabetic foot in the general surgery diabetic foot clinic and were hospitalized for surgery. The relationships between the HbA1c levels of the patients with the Wagner and PEDIS (Perfusion, Extent, Dept, Infection, Sensation) classification system grades, and the surgical procedures performed were analyzed and the treatment outcomes were evaluated.
resultsIt was determined that there was a 90% statistically significant relationship between HbA1c values of ≥10.1% and the de-velopment of Wagner Grade 4 diabetic foot ulcer (DFU) (P=0.037). A strong statistically significant relationship at the rate of 85% was determined between HbA1c values of ≥10.1% and the development of PEDIS Grade 3 ulcers. As the HbA1c values increased, so there was determined to be a statistically significant relationship with the development of PEDIS Grade 3 ulcer (P=0.003). In the comparison of the HbA1c values according to the type of surgery performed, a weak relationship was determined at the rate of 26%, and it was determined that as the HbA1c values increased, so there could be an increase in the amputation level.
conclusionThe results of this study showed that as HbA1c values at diagnosis increased in patients with diabetic foot; Wagner/PEDIS grades, disease severity, surgical extension, amputation level, and tissue loss increased. To reduce the severity of diabetic foot disease and prevent amputation, compliance with diabetic treatment and glycemic control should be increased.
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