ReviewPsychological medicine2023
A revitalized biopsychosocial model: core theory, research paradigms, and clinical implications.
Review in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
81 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Assessing Financial Toxicity in Cancer: A Global Systematic Review and Meta-Analysis Using an Asset Framework.Cancer medicine · 2026Pooled it
- Meta-synthesis of qualitative research on family caregiving experiences for individuals with cognitive impairment: a systematic review.Frontiers in public health · 2025Pooled it
- Exploring the relationship between social media dependence and internet addiction among college students from a bibliometric perspective.Frontiers in psychology · 2025Pooled it
- Influence of patient-reported outcomes on the effect of exercise therapy, manual therapy, and kinesiotaping in chronic low back pain: secondary statistical analysis.Scientific reports · 2025Trial
- Coping with suicidal crisis in Kalaallit Nunaat (Greenland): inuit youth lived experiences of recovery and protective processes - a qualitative pilot study.International journal of circumpolar health · 2026Article
- Prevalence and associated factors of kinesiophobia in postoperative patients with breast cancer: A systematic review and meta-analysis.Asia-Pacific journal of oncology nursing · 2026Review
- Assessing the Need for Mental Health Support From Free-Text Responses: Development and Validation of Language-Based Assessments in Adults With Internalizing Symptoms.JMIR mental health · 2026Article
- Measurement of Spiritual Fitness Among Healthcare Professionals in Türkiye: Psychometric Properties of the Turkish Version of the SOCOM Spiritual Fitness Scale.Journal of religion and health · 2026Article
- Examining the role of social workers within clinical metabolic genetics care.Molecular genetics and metabolism reports · 2026Review
- Permissive and instructive causality: integrating biological and environmental factors in mental health.Psychological medicine · 2026Review
- Autonomic Dysfunction, Psychosocial Factors, and Pain Sensitivity in Persistent Spinal Pain: A Systematic Review.Journal of clinical medicine · 2026Review
- Analysis of health anxiety trajectories in rabies exposure patients based on machine learning.BMC public health · 2026Article
- Quality of Life in Adolescents with Idiopathic Scoliosis: A Longitudinal Study Exploring the Impact of Psychological Distress, Joint Hypermobility, Body Mass Index, and Physical Activity.Journal of clinical medicine · 2026Article
- Emotion Classification in Japanese Cancer Survivor Interview Narratives Using Sentiment Polarity and Plutchik Emotion Frameworks: Model Development and Evaluation Study.JMIR formative research · 2026Article
- Perceived social support and its impact on alcohol treatment outcomes: a qualitative study among women with HIV enrolled in a clinical alcohol pharmacotherapy trial.AIDS research and therapy · 2026Article
- TMD and Bruxism as Expressions of Central Regulatory State: The Functional Occlusion Regulated Model (FORM).Journal of clinical medicine · 2026Review
- Sexual desire and associated factors among older adults living with HIV: a cross-sectional study.BMC public health · 2026Article
- Comprehensive Model for Mental health Access and service use (CoMMA): A process model for technology-enhanced mental healthcare.Internet interventions · 2026Review
- Treatment Adherence, Psychosocial Factors, and Clinical Outcomes in Repeatedly Hospitalized Patients with Rheumatoid Arthritis and Ankylosing Spondylitis: An Exploratory Mid-Term Longitudinal Mixed-Effects Study.Medical sciences (Basel, Switzerland) · 2026Observational
- Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author.
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Abstract
The biopsychosocial model (BPSM) was proposed by George Engel in 1977 as an improvement to the biomedical model (BMM), to take account of psychological and social as well as biological factors relevant to health and disease. Since then the BPSM has had a mixed reputation, as the overarching framework for psychiatry, perhaps for medicine generally, while also being criticized for being theoretically and empirically vacuous. Over the past few decades, substantial evidence has accumulated supporting the BPSM but its theory remains less clear. The first part of this paper reviews recent well-known, general theories in the relevant sciences that can provide a theoretical framework of the model, constituting a revitalized BPSM capable of theorizing causal interactions within and between biological, psychological, and social domains. Fundamental concepts in this new framework include causation as regulation and dysfunction as dysregulation. Associated research paradigms are outlined in Part 2. Research in psychological therapies and social epidemiology are major examples of programs that have produced results anomalous for the BMM and consistent with the BPSM. Theorized models of causal mechanisms enrich empirical data and two biopsychosocial examples are models of chronic stress and pain perception. Clinical implications are reviewed in Part 3. The BPSM accommodates psychological and social as well as biological treatment effects evident in the clinical trials literature. Personal, interpersonal, and institutional aspects of clinical care are out of the scope of the BMM, assigned to the art of healthcare rather than the science, but can be accommodated and theorized in the BPSM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.