ArticleFrontiers in neuroscience2023
Learning-dependent structural plasticity of intracortical and sensory connections to functional domains of the olfactory tubercle.
Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Olfactory tubercle mediates adaptive social behavior by controlling threat assessment and the expression of social threat memories during recall in male mice.Nature communications · 2026Article
- Multimodal characterization of transcriptionally defined ventral tegmental area dopamine neurons.bioRxiv : the preprint server for biology · 2026Article
- Editorial: The diversity of the plasticitome.Frontiers in synaptic neuroscience · 2026Article
- Differential potentiation of odor aversion and yawning by melanocortin 4 receptor signaling in distinct regions of the ventral striatum.Frontiers in neuroscience · 2025Article
- Function of orexin-1 receptor signaling in the olfactory tubercle in odor-guided attraction and aversion.Communications biology · 2024Article
- Circuit dynamics of the olfactory pathway during olfactory learning.Frontiers in neural circuits · 2024Review
- Connectivity of the olfactory tubercle: inputs, outputs, and their plasticity.Frontiers in neural circuits · 2024Review
- Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life.Frontiers in neural circuits · 2024Review
- Synaptic plasticity and roles of orexin in distinct domains of the olfactory tubercle.Frontiers in neural circuits · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The olfactory tubercle (OT), which is a component of the olfactory cortex and ventral striatum, has functional domains that play a role in odor-guided motivated behaviors. Learning odor-guided attractive and aversive behavior activates the anteromedial (am) and lateral (l) domains of the OT, respectively. However, the mechanism driving learning-dependent activation of specific OT domains remains unknown. We hypothesized that the neuronal connectivity of OT domains is plastically altered through olfactory experience. To examine the plastic potential of synaptic connections to OT domains, we optogenetically stimulated intracortical inputs from the piriform cortex or sensory inputs from the olfactory bulb to the OT in mice in association with a food reward for attractive learning and electrical foot shock for aversive learning. For both intracortical and sensory connections, axon boutons that terminated in the OT domains were larger in the amOT than in the lOT for mice exhibiting attractive learning and larger in the lOT than in the amOT for mice exhibiting aversive learning. These results indicate that both intracortical and sensory connections to the OT domains have learning-dependent plastic potential, suggesting that this plasticity underlies learning-dependent activation of specific OT domains and the acquisition of appropriate motivated behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.