Evidence map›Paper›PMID 37680750›Full record

ArticleFrontiers in cellular and infection microbiology2023

The caecal microbiota promotes the acute inflammatory response and the loss of the intestinal barrier integrity during severe

Florian Tomal, Guillaume Sadrin, Pauline Gaboriaud, Edouard Guitton, Laura Sedano, Nathalie Lallier, Christelle Rossignol, Thibaut Larcher, Elodie Rouille, Mireille Ledevin and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

  1. Animals : an open access journal from MDPI · 2026
    Review
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  15. Frontiers in immunology · 2025
    Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Florian TomalINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Guillaume SadrinINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Pauline GaboriaudINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Edouard GuittonINRAE, UE PFIE, Nouzilly, France.
Laura SedanoINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Nathalie LallierINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Christelle RossignolINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Thibaut LarcherINRAE, Oniris, PAnTher, APEX, Nantes, France.
Elodie RouilleINRAE, Oniris, PAnTher, APEX, Nantes, France.
Mireille LedevinINRAE, Oniris, PAnTher, APEX, Nantes, France.
Rodrigo GuabirabaINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Anne SilvestreINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Sonia Lacroix-LamandéINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Catherine SchoulerINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Fabrice LaurentINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Françoise I BussièreINRAE, Université de Tours, UMR ISP, Nouzilly, France.
Université de Tours · FRInfectiologie Animale et Santé Publique · FRInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FROniris · FRMontpellier GenomiX · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Coccidiosis, a disease caused by intestinal apicomplexan parasites Objective: The objective of this study is to investigate the role of the microbiota in the pathogenesis of severe Methods: We have previously shown that microbiota can promote parasite development. To study the effect of the microbiota on the pathogenesis of this infection, we used an experimental condition (inoculum of 10 000 oocysts Results: Our results demonstrated caecal lesions and epithelium damage in conventional chickens at 7 days pi but not in germ-free infected chickens. Administration of conventional microbiota to germ-free chickens partially restored these deleterious effects. At day 7 pi, both infected conventional and germ-free chickens exhibited increased gene expression of inflammatory mediators, including Conclusion: These observations imply that, during

Indexed as

CoccidiosisEimeria tenellaAnimalsChickensCyclooxygenase 2InflammationInterleukin-18Cyclooxygenase 2Interleukin-18bacterial translocationchickenEimeria tenellagerm-freeinflammationmicrobiota

Identifiers

PMID37680750
PMCPMC10482108
OpenAlexW4386090068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.