Evidence map›Paper›PMID 37680671›Full record

ArticleBrain communications2023

Neuroimaging, clinical and life course correlates of normal-appearing white matter integrity in 70-year-olds.

Sarah-Naomi James, Emily N Manning, Mathew Storey, Jennifer M Nicholas, William Coath, Sarah E Keuss, David M Cash, Christopher A Lane, Thomas Parker, Ashvini Keshavan and 19 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 7 institutions in 2 countries.

Sarah-Naomi JamesMRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK.ORCID https://orcid.org/0000-0002-3800-4416
Emily N ManningDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID https://orcid.org/0000-0002-4505-3611
Mathew StoreyDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Jennifer M NicholasDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
William CoathDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID https://orcid.org/0000-0002-3976-9461
Sarah E KeussDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
David M CashDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID https://orcid.org/0000-0001-7833-616X
Christopher A LaneDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Thomas ParkerDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Ashvini KeshavanDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Sarah M BuchananDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Aaron WagenDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Mathew HarrisDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID https://orcid.org/0000-0001-5785-4830
Ian MaloneDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID https://orcid.org/0000-0001-7512-7856
Kirsty LuDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID https://orcid.org/0000-0002-8416-2183
Louisa P NeedhamMRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK.
Rebecca StreetDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
David ThomasNeuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK.
John DicksonInstitute of Nuclear Medicine, University College London Hospitals Foundation Trust, London, UK.
Heidi Murray-SmithDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK.
Tamar FreibergerDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Sebastian J CrutchDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Nick C FoxDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Marcus RichardsMRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK.ORCID https://orcid.org/0000-0001-9191-2192
Frederik BarkhofCentre for Medical Image Computing, University College London, London, UK.
Carole H SudreMRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK.
Josephine BarnesDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Jonathan M SchottMRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK.ORCID https://orcid.org/0000-0003-2059-024X
UK Dementia Research Institute · GBMRC Unit for Lifelong Health and Ageing · GBAmsterdam University Medical Centers · NLKing's College London · GBLondon School of Hygiene & Tropical Medicine · GBPhysiological Society · GBUniversity College London Hospitals NHS Foundation Trust · GB

Funding

Medical Research Council MC_UU_00019/3
6 · The paper itself

Abstract

We investigate associations between normal-appearing white matter microstructural integrity in cognitively normal ∼70-year-olds and concurrently measured brain health and cognition, demographics, genetics and life course cardiovascular health. Participants born in the same week in March 1946 (British 1946 birth cohort) underwent PET-MRI around age 70. Mean standardized normal-appearing white matter integrity metrics (fractional anisotropy, mean diffusivity, neurite density index and orientation dispersion index) were derived from diffusion MRI. Linear regression was used to test associations between normal-appearing white matter metrics and (i) concurrent measures, including whole brain volume, white matter hyperintensity volume, PET amyloid and cognition; (ii) the influence of demographic and genetic predictors, including sex, childhood cognition, education, socio-economic position and genetic risk for Alzheimer's disease (

Indexed as

brain healthdiffusionmicrostructural integritynormal-appearing white mattervascular risk

Identifiers

PMID37680671
PMCPMC10481255
OpenAlexW4385970839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.