Evidence map›Paper›PMID 37680469›Full record

ArticleiScience2023

Molecular evolution and targeted recombination of SARS-CoV-2 in South Korea.

Atanas V Demirev, Kyuyoung Lee, Joon-Yong Bae, Heedo Park, Sejik Park, Hyunbeen Kim, Jungmin Lee, Junhyung Cho, Jeong-Sun Yang, Kyung-Chang Kim and 5 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Atanas V DemirevDepartment of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, Republic of Korea.
Kyuyoung LeeDepartment of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, Republic of Korea.
Joon-Yong BaeDepartment of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, Republic of Korea.
Heedo ParkDepartment of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, Republic of Korea.
Sejik ParkDepartment of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, Republic of Korea.
Hyunbeen KimDepartment of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, Republic of Korea.
Jungmin LeeDepartment of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, Republic of Korea.
Junhyung ChoDivision of Emerging Viral Diseases and Vector Research, Center for Infectious Diseases Research, National Institute of Infectious Diseases, Korea National Institute of Health, Osong, Republic of Korea.
Jeong-Sun YangDivision of Emerging Viral Diseases and Vector Research, Center for Infectious Diseases Research, National Institute of Infectious Diseases, Korea National Institute of Health, Osong, Republic of Korea.
Kyung-Chang KimDivision of Emerging Viral Diseases and Vector Research, Center for Infectious Diseases Research, National Institute of Infectious Diseases, Korea National Institute of Health, Osong, Republic of Korea.
Joo-Yeon LeeCenter for Infectious Diseases Research, National Institute of Infectious Diseases, Korea National Institute of Health, Osong, Republic of Korea.
Kisoon KimDepartment of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, Republic of Korea.
Philippe LemeyDepartment of Microbiology, Immunology, and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Man-Seong ParkDepartment of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, Republic of Korea.
Jin Il KimDepartment of Microbiology, Institute for Viral Diseases, Korea University College of Medicine, Seoul, Republic of Korea.
Korea University · KRKorea National Institute of Health · KRRega Institute for Medical Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 variants have continuously emerged globally, including in South Korea. To characterize the molecular evolution of SARS-CoV-2 in South Korea, we performed phylogenetic and genomic recombination analyses using more than 12,000 complete genome sequences collected until October 2022. The variants in South Korea originated from globally identified variants of concern and harbored genetic clade-common and clade-specific amino acid mutations mainly around the N-terminal domain (NTD) or receptor binding domain (RBD) in the spike protein. Several point mutation residues in key antigenic sites were under positive selection persistently with changing genetic clades of SARS-CoV-2. Furthermore, we detected 17 potential genomic recombinants and 76.4% (13/17) retained the mosaic NTD or RBD genome. Our results suggest that point mutations and genomic recombination in the spike contributed to the molecular evolution of SARS-CoV-2 in South Korea, which will form an integral part of global prevention and control measures against SARS-CoV-2.

Indexed as

PhylogeneticsVirology

Identifiers

PMID37680469
PMCPMC10481354
OpenAlexW4386024718

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.