Evidence map›Paper›PMID 37680223›Full record

ArticleTranslational andrology and urology2023

Molecular mechanisms of penile traction for penile rehabilitation in a bilateral cavernous nerve crush injury rat model.

Brian Dick, Jacob W Greenberg, Michael Polchert, Max Moore, Joseph Kim, Cameron Belding, Hogyoung Kim, Suresh C Sikka, Asim Abdel-Mageed, Shams Halat and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational andrology and urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Brian Dick *Department of Urology, University of California San Francisco, San Francisco, CA, USA.
Jacob W Greenberg *Department of Urology, School of Medicine, Tulane University, New Orleans, LA, USA.
Michael PolchertDepartment of Urology, School of Medicine, Tulane University, New Orleans, LA, USA.
Max MooreSchool of Science and Engineering, Tulane University, New Orleans, LA, USA.
Joseph KimDepartment of Urology, School of Medicine, Tulane University, New Orleans, LA, USA.
Cameron BeldingDepartment of Urology, School of Medicine, Tulane University, New Orleans, LA, USA.
Hogyoung KimDivision of Basic Pharmaceutical Sciences, Xavier University, New Orleans, LA, USA.
Suresh C SikkaDepartment of Urology, School of Medicine, Tulane University, New Orleans, LA, USA.
Asim Abdel-MageedDepartment of Urology, School of Medicine, Tulane University, New Orleans, LA, USA.
Shams HalatDepartment of Pathology, Tulane University, School of Medicine, New Orleans, LA, USA.
Wayne J G HellstromDepartment of Urology, School of Medicine, Tulane University, New Orleans, LA, USA.
Tulane University · USUniversity of California, San Francisco · USXavier University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prostate cancer is the most common solid-organ malignancy in adult men. Early detection and treatment of prostate cancer with radical prostatectomy (RP) has improved cancer-specific survival but is associated with penile shortening and erectile dysfunction. Penile traction therapy (PTT) has been demonstrated to increase stretched penile length (SPL) prior to penile prosthesis placement and may improve erectile function (EF) in patients with Peyronie's disease. We aimed to evaluate the efficacy of PTT in preserving penile length and EF after bilateral cavernous nerve crush injury (BCNI) in a rat model. Methods: Twenty-four male Sprague-Dawley rats aged 11-13 weeks were randomly assigned to three groups (n=8, each): sham operation with no PTT (Sham), BCNI without PTT (Crush), and BCNI with PTT (Traction). PTT was started on postoperative day 3. A traction force of 1 Newton was applied to the penis for 30 minutes each day for 28 days. After 28 days of traction, the cavernous nerve was stimulated while recording the intracavernosal pressure (ICP) and the mean arterial pressure (MAP) simultaneously. Cavernosal tissue was excised, and western blot analysis for endothelial nitric oxide synthase (eNOS) was performed. Significance was determined by using ANOVA with Tukey-Kruger post-hoc testing. Results: At 4 weeks after nerve injury, the Traction group had significantly greater SPL compared to the Sham and Crush groups (30 Conclusions: Findings from this animal study suggest that PTT has the potential to mitigate penile retraction after RP. While more studies are needed to determine the effect of PTT on preservation of EF, the increased eNOS expression observed in the Traction group offers a potential protective mechanism of action.

Indexed as

endothelial nitric oxide synthase (eNOS)erectile dysfunctionmechanism of actionPenile rehabilitationpenile traction therapy (PTT)

Identifiers

PMID37680223
PMCPMC10481190
OpenAlexW4386170815

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.