Evidence map›Paper›PMID 37680149›Full record

ArticleCombinatorial chemistry & high throughput screening2024

Lncrna CASC15 Activated By TCF12 Promote Colorectal Cancer Progression

Shuai Yan, Ming Yuan, Xichen Yang, Xianting Huang, Dan Wu, Nanyao Wang, Xia Sun, Ya Qin, Yanhua Fei, Zhenguo Zhao and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Combinatorial chemistry & high throughput screening, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Shuai YanDepartment of Oncology, Jiangyin People's Hospital Affiliated to Nantong University, No. 163 Shoushan Rd, Jiangyin, Jiangsu Province, 214400, China.
Ming YuanDepartment of Oncology, Jiangyin People's Hospital Affiliated to Nantong University, No. 163 Shoushan Rd, Jiangyin, Jiangsu Province, 214400, China.
Xichen YangDepartment of Pediatrics, Jiangyin People's Hospital Affiliated to Nantong University, No. 163 Shoushan Rd, Jiangyin, Jiangsu Province, 214400, China.
Xianting HuangDepartment of Oncology, Jiangyin People's Hospital Affiliated to Nantong University, No. 163 Shoushan Rd, Jiangyin, Jiangsu Province, 214400, China.
Dan WuDepartment of Oncology, Jiangyin People's Hospital Affiliated to Nantong University, No. 163 Shoushan Rd, Jiangyin, Jiangsu Province, 214400, China.
Nanyao WangDepartment of Oncology, Jiangyin People's Hospital Affiliated to Nantong University, No. 163 Shoushan Rd, Jiangyin, Jiangsu Province, 214400, China.
Xia SunDepartment of Oncology, Jiangyin People's Hospital Affiliated to Nantong University, No. 163 Shoushan Rd, Jiangyin, Jiangsu Province, 214400, China.
Ya QinDepartment of Oncology, Jiangyin People's Hospital Affiliated to Nantong University, No. 163 Shoushan Rd, Jiangyin, Jiangsu Province, 214400, China.
Yanhua FeiDepartment of Oncology, Jiangyin People's Hospital Affiliated to Nantong University, No. 163 Shoushan Rd, Jiangyin, Jiangsu Province, 214400, China.
Zhenguo ZhaoDepartment of General Surgery, Jiangyin People's Hospital Affiliated to Nantong University, No. 163 Shoushan Rd, Jiangyin, Jiangsu Province, 214400, China.
Qiong WangDepartment of Oncology, Jiangyin People's Hospital Affiliated to Nantong University, No. 163 Shoushan Rd, Jiangyin, Jiangsu Province, 214400, China.
Jiangyin People's Hospital · CNNantong University · CN

Funding

General project of Wuxi Municipal Health Commission MS201908Jiangsu Key Laboratory of Immunity and Metabolism XZSYSKF2020015Wuxi precision medicine project J202009Wuxi "Taihu Lake Talent Plan" medical and health high-level talent project 2020103
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is one of the most common gastrointestinal malignancies. LncRNA CASC15 has also been found to play a vital role in malignant tumors.

objectiveOur objective is to explore the role of CASC15 in colorectal cancer and its regulation of EMT and to clarify the reasons for its up-regulated expression in CRC.

methodsQuantitative real-time PCR was performed to evaluate the expression of CASC15 in CRC. The biology function of CASC15 on CRC was assessed by

resultsWe found that CASC15 was remarkably upregulated in CRC and positively correlated with poorer relapse-free survival. CASC15 knockdown significantly suppressed the proliferation and migration of CRC. Furthermore, CASC15 downregulation mediated apoptosis of CRC. Mechanistically, TCF12 activates CASC15 transcription to mediate its up-regulation, which activates EMT and promotes CRC progression.

conclusionOur study identified TCF12/CASC15/EMT as a new regulatory signal axis of CRC. CASC15 may be a new molecular marker and target for CRC.

Indexed as

Cell ProliferationColorectal NeoplasmsEpithelial-Mesenchymal TransitionRNA, Long NoncodingApoptosisBasic Helix-Loop-Helix ProteinsCell Line, TumorCell MovementDisease ProgressionGene Expression Regulation, NeoplasticHumansBasic Helix-Loop-Helix ProteinsRNA, Long NoncodingTCF12 protein, humanCASC15CRCEMTmigration.proliferationTCF12

Identifiers

PMID37680149
OpenAlexW4386531258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.