Evidence map›Paper›PMID 37680034›Full record

ArticleHistopathology2023

Novel EWSR1::GFI1B gene fusion in angiofibroma of soft tissue.

Albert J H Suurmeijer, Arjen H G Cleven, Cristina R Antonescu, Lauren A Duckworth, Karen J Fritchie, Steven D Billings, Josephine K Dermawan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Histopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Albert J H SuurmeijerDepartment of Pathology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Arjen H G ClevenDepartment of Pathology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Cristina R AntonescuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID https://orcid.org/0000-0002-9717-8205
Lauren A DuckworthRobert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-6866-6760
Karen J FritchieRobert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Steven D BillingsRobert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-2278-5908
Josephine K DermawanRobert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-1139-2914
Cleveland Clinic · USUniversity Medical Center Groningen · NLMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Targeting Oncogenic Pathways in Genetically Complex SarcomasP50CA217694 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Marc Ladanyi · 2018 to 2026
$21.5M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA217694
6 · The paper itself

Abstract

aimsAngiofibroma of soft tissue is a benign soft tissue tumour characterised by bland spindle cells and a distinct branching vascular network. The majority of soft tissue angiofibromas harbour AHRR::NCOA2 gene fusions. Here we present three cases of EWSR1::GFI1B-fused soft tissue tumours that are morphologically most reminiscent of soft tissue angiofibroma. METHODS AND

resultsAll three cases presented in male patients with an age range of 35-78 years (median = 54 years). Two cases presented as subcutaneous nodules on the trunk (posterior neck and chest wall); one was an intramuscular foot mass. The tumours were unencapsulated nodules with infiltrative margins ranging from 2.2 to 3.4 cm in greatest dimension. Histologically, the tumours contained uniformly bland fibroblastic spindle cells with ovoid to fusiform nuclei and delicate cytoplasmic processes embedded in a myxoid to myxocollagenous stroma. All three cases were characterised by a thin-walled, branching vascular network evenly distributed throughout the tumour. Overt cytological atypia or conspicuous mitotic activity was absent. The spindle cells had an essentially null immunophenotype. By targeted RNA sequencing, an in-frame gene fusion between EWSR1 exons 1-7 and GFI1B exons 6-11 or 7-11 was detected in all three cases. The tumours were marginally excised. For all three cases, there were no documented local recurrence or distant metastases during a limited follow-up period of 6-10 months.

conclusionsWe propose that EWSR1::GFI1B may represent a novel fusion variant of soft tissue angiofibroma.

Indexed as

AngiofibromaHead and Neck NeoplasmsSoft Tissue NeoplasmsAdultAgedExonsGene FusionHumansMaleMiddle AgedProto-Oncogene ProteinsRepressor ProteinsRNA-Binding Protein EWSEWSR1 protein, humanGFI1B protein, humanProto-Oncogene ProteinsRepressor ProteinsRNA-Binding Protein EWSEWSR1GFI1Bsoft tissue angiofibroma

Identifiers

PMID37680034
PMCPMC11423792
OpenAlexW4386530668

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.