ArticleBrain and behavior2023
Enhanced rich club connectivity in mild or moderate depression after nonpharmacological treatment: A preliminary study.
Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Incomplete network restoration may be associated with higher relapse risk in women with major depressive disorder.Psychiatry and clinical neurosciences · 2026Article
- Disrupted rich club organization in structural brain networks is related to childhood maltreatment in major depressive disorder.Frontiers in psychiatry · 2026Article
- Changes in Neural Activities and Neuroplasticity Related to Nonpharmacological Interventions for Major Depressive Disorder: A Systematic Literature Review.Biological psychiatry global open science · 2025Review
- Long-term risk of late-life depression in widowed elderly: a five-year follow-up study.BMC geriatrics · 2025Article
- Is depression a global brain disorder with topographic dynamic reorganization?Translational psychiatry · 2024Review
- Enhanced rich club connectivity in mild or moderate depression after nonpharmacological treatment: A preliminary study.Brain and behavior · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
introductionIt has been suggested that the rich club organization in major depressive disorder (MDD) was altered. However, it remained unclear whether the rich club organization could be served as a biomarker that predicted the improvement of clinical symptoms in MDD.
methodsThe current study included 29 mild or moderate patients with MDD, who were grouped into a treatment group (receiving cognitive behavioral therapy or real-time fMRI feedback treatment) and a no-treatment group. Resting-state MRI scans were obtained for all participants. Graph theory was employed to investigate the treatment-related changes in network properties and rich club organization.
resultsWe found that patients in the treatment group had decreased depressive symptom scores and enhanced rich club connectivity following the nonpharmacological treatment. Moreover, the changes in rich club connectivity were significantly correlated with the changes in depressive symptom scores. In addition, the nonpharmacological treatment on patients with MDD increased functional connectivity mainly among the salience network, default mode network, frontoparietal network, and subcortical network. Patients in the no-treatment group did not show significant changes in depressive symptom scores and rich club organization.
conclusionsThose results suggested that the remission of depressive symptoms after nonpharmacological treatment in MDD patients was associated with the increased efficiency of global information processing.
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