ArticleDevelopmental medicine and child neurology2024
Linking corticospinal tract activation and upper-limb motor control in adults with cerebral palsy.
Article in Developmental medicine and child neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- Cervicothoracic dorsal rhizotomy for the management of upper limb spasticity: a systematic review.Neurosurgical review · 2025Pooled it
- Stem Cell-Derived Exosomes Improve Neurological Dysfunction in a Rat Model of Moderate-to-Severe Cerebral Palsy.Stem cell reviews and reports · 2026Article
- Adjunctive dry needling reduces spasticity and improves functional outcomes in children with cerebral palsy: a single-blind randomized controlled trial.Frontiers in pediatrics · 2026Article
- Transition Aged Individuals With Cerebral Palsy Have Larger Clinical Gains With Visual Performance Feedback During Power Training.Archives of rehabilitation research and clinical translation · 2025Article
- Adults with cerebral palsy exhibit uncharacteristic cortical oscillations during an adaptive sensorimotor control task.Scientific reports · 2024Article
- Cervicomedullary motor evoked responses in individuals with severe chronic hemiparesis post-stroke: a feasibility study.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimTo quantify the cervicomedullary motor evoked potentials (CMEPs) at the cervical spinal level in adults with cerebral palsy (CP) and determine if altered CMEPs are linked with upper-extremity motor function in this population.
methodThis cross-sectional study consisted of a cohort of adults with CP (n = 15; mean age = 33 years 5 months [SD = 11 years 8 months]); Manual Ability Classification System levels I-IV) and neurotypical controls (n = 18; mean age = 30 years 10 months [SD = 10 years 4 months]), who were recruited to participate at an academic medical center. Adults with CP and typical adults (controls) were stimulated at the cervicomedullary junction to assess CMEPs at the cervical spinal cord level. Upper-extremity motor function was quantified using the Box and Blocks and Purdue Pegboard tests, self-reported upper-extremity function (UEF), and assessments of selective motor control.
resultsAt higher stimulation levels, the contralateral CMEP responses of adults with CP were different from typical adults (p = 0.032). Reduced CMEP was correlated with reduced upper-limb function, including worse performance on the Box and Blocks (rho = 0.625, p = 0.025) and Purdue Pegboard tests (rho = 0.701, p = 0.010), lower self-reported UEF (rho = 0.761, p = 0.009), and overall selective motor control (rho = 0.731, p = 0.007).
interpretationChanges in the activation of spinal motoneurons through corticospinal pathways may have an important role in the altered upper-extremity motor function of individuals with CP.
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Registered trials
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