ArticleDiabetology & metabolic syndrome2023
The triglyceride glucose index was U-shape associated with all-cause mortality in population with cardiovascular diseases.
Article in Diabetology & metabolic syndrome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- The impact of triglyceride-glucose index on short-term prognosis in patients with acute myocarditis.BMC cardiovascular disorders · 2026Article
- TyG Index and Frailty as Composite Biomarkers of Cardiometabolic Risk and Mortality Across CKM Stages 0-3.Metabolites · 2026Article
- Triglyceride-glucose index and anti-Ro52 antibody for identification of cardiovascular disease in patients with primary Sjögren's disease.Lipids in health and disease · 2026Article
- A comprehensive study on the uric acid to high-density cholesterol ratio influencing cardiometabolic-based chronic disease in China.Frontiers in nutrition · 2026Article
- DNA methylation markers of insulin resistance surrogate measures in the Atherosclerosis Risk in Communities (ARIC) study.Epigenetics · 2025Article
- Nonlinear relationship between triglyceride-glucose index and cardiovascular mortality with competing risk analysis on populations aged 18-80 years.BMC cardiovascular disorders · 2025Article
- The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study.Cardiovascular diabetology · 2025Article
- Association between five novel anthropometric indices and erectile dysfunction in US adults from NHANES database.Scientific reports · 2025Article
- Associations of triglyceride-glucose index with N-terminal pro-B-type natriuretic peptide and mortality in middle-aged and elderly individuals.Frontiers in endocrinology · 2025Article
- The association between the triglyceride-glucose index with all-cause and cardiovascular mortality within the infertility population.PloS one · 2025Article
- Exploring BMI's mediating influence on cardiovascular risk correlations with the triglyceride-glucose index: using NHANES and CHARLS cohorts.Frontiers in cardiovascular medicine · 2025Article
- Correlation of the triglyceride-glucose-body mass index with all-cause and cardiovascular mortality in patients undergoing peritoneal dialysis: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Predictive value of the triglyceride-glucose index for short- and long-term all-cause mortality in patients with critical coronary artery disease: a cohort study from the MIMIC-IV database.Lipids in health and disease · 2024Article
- Non-linear association of triglyceride-glucose index with cardiovascular and all-cause mortality in T2DM patients with diabetic kidney disease: NHANES 2001-2018 retrospective cohort study.Lipids in health and disease · 2024Article
- Association of the triglyceride-glucose index with all-cause and cause-specific mortality: a population-based cohort study of 3.5 million adults in China.The Lancet regional health. Western Pacific · 2024Article
- Association between metabolic score for insulin resistance and clinical outcomes: insights from the Tehran lipid and glucose study.Nutrition & metabolism · 2024Article
- Triglyceride-glucose index predicts all-cause mortality, but not cardiovascular mortality, in rural Northeast Chinese patients with metabolic syndrome: a community-based retrospective cohort study.Nutrition & metabolism · 2024Article
- The impact of triglyceride glucose-body mass index on all-cause and cardiovascular mortality in elderly patients with diabetes mellitus: evidence from NHANES 2007-2016.BMC geriatrics · 2024Article
- Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population.Cardiovascular diabetology · 2024Article
- Non-linear associations of HOMA2-IR with all-cause mortality in general populations: insights from NHANES 1999-2006.BMC public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe triglyceride and glucose (TyG) index has been considered a simple surrogate marker of insulin resistance, related to a high risk of mortality. However, few studies have investigated the specific relationship between the TyG index and all-cause mortality among population with cardiovascular diseases.
methods2,072 participants with cardiovascular diseases were enrolled from the National Health and Nutrition Examination Survey (NHANES) 1999-2014. The TyG index was calculated as log [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. Outcomes were all-cause mortality and cardiovascular mortality. The baseline levels of TyG associated with the risk of mortality were evaluated on a continuous scale (restricted cubic splines) and by a priori defined quantile categories with Cox regression models.
resultsAfter a follow-up of 16.8 years, 791 all-cause deaths and 184 cardiovascular deaths occurred. Restricted cubic splines showed that the association between levels of TyG index and the risk of all-cause mortality was non-linear (p < 0.001) and the TyG index associated with the lowest risk of all-cause mortality ranges 8.83 to 9.06 in individuals with cardiovascular diseases. Compared with the reference quartile of 8.84 ~ 9.29, the multivariate-adjusted hazards ratios and 95% confidence intervals were 1.40 (1.13-1.74; p = 0.002) in the lowest quartile and 1.08 (0.88, 1.32; p = 0.475) in the highest quartile for all-cause mortality. However, TyG was not associated with cardiovascular mortality.
conclusionsTyG index was U-shape associated with the risk of all-cause mortality in participants with cardiovascular diseases and the level associated with the lowest risk ranged 8.83 to 9.06.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.