Evidence map›Paper›PMID 37679763›Full record

SynthesisCardiovascular diabetology2023

Triglyceride-glucose index and heart failure: a systematic review and meta-analysis.

Amirmohammad Khalaji, Amir Hossein Behnoush, Shaghayegh Khanmohammadi, Kimiya Ghanbari Mardasi, Sourena Sharifkashani, Amirhossein Sahebkar, Caterina Vinciguerra, Alessandro Cannavo

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07164222 (Triglycerides Glucose Index on Diabetic Patients Type 2), which is not on this map. Cited by 125 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 18 pooled it
34.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07164222 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Triglycerides Glucose Index on Diabetic Patients Type 2

TypeobservationalSponsorAssiut UniversityRan2025 to 2027Enrolled200ConditionsTriglycerides Glucose Index and Ratio on Diabetic Type 2ArmsGlycated haemoglobin and triglycerides level
3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 18 syntheses or guidelines pooled it, 153 citations in OpenAlex.

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65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Amirmohammad KhalajiSchool of Medicine, Tehran University of Medical Sciences, Poursina St., Keshavarz Blvd., 1417613151, Tehran, Iran.
Amir Hossein BehnoushSchool of Medicine, Tehran University of Medical Sciences, Poursina St., Keshavarz Blvd., 1417613151, Tehran, Iran. amirhossein.behnoush@gmail.com.
Shaghayegh KhanmohammadiSchool of Medicine, Tehran University of Medical Sciences, Poursina St., Keshavarz Blvd., 1417613151, Tehran, Iran.
Kimiya Ghanbari MardasiStudent Research Committee, Alborz University of Medical Sciences, Karaj, Iran.
Sourena SharifkashaniSchool of Medicine, Tehran University of Medical Sciences, Poursina St., Keshavarz Blvd., 1417613151, Tehran, Iran.
Amirhossein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Caterina VinciguerraDepartment of Translational Medicine Sciences, Federico II University of Naples, Naples, Italy.
Alessandro CannavoDepartment of Translational Medicine Sciences, Federico II University of Naples, Naples, Italy.
Tehran University of Medical Sciences · IRUniversity of Naples Federico II · ITAlborz University of Medical SciencesMashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInsulin resistance (IR) is a major metabolic disorder observed in heart failure (HF) and is tightly associated with patients' poor prognosis. The triglyceride-glucose index (TyG) has been proposed as a surrogate marker of IR in HF. Yet, whether TyG is a reliable clinical marker is still under debate. Hence, we aimed to respond to this relevant question via a systematic review and meta-analysis of existing studies.

methodsA systematic search was conducted in PubMed, Embase, Scopus, and Web of Science to find studies investigating the TyG index in patients with HF or its association with the incidence of HF. Adjusted hazard ratios (HR) and 95% confidence intervals (CI) were pooled through random-effect meta-analysis. HRs were calculated using TyG as a continuous variable (1 unit increase) and by comparing the group with the highest TyG to the lowest TyG group.

resultsThirty studies, involving 772,809 participants, were included in this systematic review. Meta-analysis of seven studies comparing the highest-TyG to the lowest-TyG group showed a significantly increased risk of HF in the former group (HR 1.21, 95% CI 1.14 to 1.29, P < 0.01). The same result was found when pooling the HRs for a one-unit increase in the TyG index (HR 1.17, 95% CI 1.08 to 1.26). Similarly, a more elevated TyG index was associated with a higher incidence of HF in patients with type 2 diabetes or coronary artery disease. Additionally, the incidence of adverse events (readmission and mortality) in patients with HF was associated with TyG.

conclusionOur findings support the TyG index as a valuable marker to assess the risk of HF incidence in different populations and as a prognostic marker in patients with HF. Further studies should be conducted to confirm these associations and investigate the clinical utility of the TyG index.

Indexed as

Coronary Artery DiseaseDiabetes Mellitus, Type 2Heart FailureInsulin ResistanceGlucoseHumansTriglyceridesGlucoseTriglyceridesBlood glucoseHeart failureInsulin resistanceMeta-analysisSystematic reviewTriglycerides

Identifiers

PMID37679763
PMCPMC10486123
OpenAlexW4386524479

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.