Evidence map›Paper›PMID 37679749›Full record

Observational studyPediatric rheumatology online journal2023

Disease evolution in systemic juvenile idiopathic arthritis: an international, observational cohort study through JIRcohort.

M Wallimann, K Bouayed, E Cannizzaro, D Kaiser, A Belot, E Merlin, S Poignant, C Wouters, F Hofer, T Saurenmann and 5 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric rheumatology online journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 4 countries.

M WallimannDepartment of Woman, Mother, Child, Unit of Pediatric Immunology, Allergology and Rheumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
K BouayedDepartment of Pediatrics, Unit of Rheumatology and Nephrology, Mother and Child University Hospital A. Harouchi, CHU Ibn Rochd, Casablanca, Morocco.
E CannizzaroDepartment of Pediatrics, Unit of Pediatric Rheumatology, University Children's Hospital, Zurich, Switzerland.
D KaiserDepartment of Pediatrics, Unit of Pediatric Rheumatology, Childrens Hospital Lucerne, Lucerne, Switzerland.
A BelotDepartment of Pediatrics, Unit of Pediatric Nephrology, Rheumatology, Dermatology, Hospital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France.
E MerlinDepartment of Pediatrics, Clermont-Ferrand University Hospital, Clermont-Ferrand, F-63000, France.
S PoignantDepartment of Pediatrics, University Hospital of Nantes, Nantes, France.
C WoutersDepartment of Pediatrics, Unit of Pediatric Rheumatology, University Hospital Leuven, Louvain, Belgium.
F HoferFondation Rhumatismes-Enfants-Suisse, Etoy, 1163, Switzerland.
T SaurenmannDepartment of Pediatrics, Cantonal Hospital Winterthur, Winterthur, Switzerland.
A KoryllouDepartment of Woman, Mother, Child, Unit of Pediatric Immunology, Allergology and Rheumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
R CarlomagnoDepartment of Woman, Mother, Child, Unit of Pediatric Immunology, Allergology and Rheumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
M MejbriDepartment of Woman, Mother, Child, Unit of Pediatric Immunology, Allergology and Rheumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
M HoferDepartment of Woman, Mother, Child, Unit of Pediatric Immunology, Allergology and Rheumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
K TheodoropoulouDepartment of Woman, Mother, Child, Unit of Pediatric Immunology, Allergology and Rheumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. aikaterini.theodoropoulou@chuv.ch.ORCID http://orcid.org/0009-0004-7745-3582
University of Lausanne · CHCentre Hospitalier Universitaire de Nantes · FRHospices Civils de Lyon · FRKantonsspital Winterthur · CHKU Leuven · BESwiss National Science Foundation · CHUniversity Children's Hospital Zurich · CHUniversity of Hassan II Casablanca · MAUniversity of Teacher Education Lucerne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSystemic juvenile idiopathic arthritis (systemic JIA) is a severe disease with both systemic and joint inflammation. This study aims to identify predictors of disease evolution within the systemic JIA population enrolled in the Juvenile Inflammatory Rheumatism cohort (JIRcohort).

methodsObservational patient cohort study with 201 recruited children from 4 countries (3 European, 1 North Africa) from 2005 until 2019, using retrospectively (2005-2015) and prospectively (2015-2019) routine care collected data.

resultsSixty-five patients with complete follow-up data for 24 months after first diagnosis were classified as monophasic (n = 23), polyphasic (n = 6) or persistent group (n = 36) corresponding to their evolution (unique flare, recurrent flares, or persistent disease activity respectively). The patients of the persistent group were more likely to have an earlier disease onset, before the age of 6 (OR 2.57, 95%-CI 0.70-9.46), persistence of arthritis at 12-months post-diagnosis (OR 4.45, 95%-CI 0.58-34.20) and higher use of synthetic DMARD (sDMARD, OR 5.28, 95%-CI 1.39-20.01). Other variables like global assessment by physician and by patient and C Reactive Protein levels at 12-months post-diagnosis were assessed but without any predictive value after adjusting for confounding factors.

conclusionsOur results suggest that the earlier disease onset, the persistence of arthritis throughout the first year of disease evolution and the need of sDMARD might predict a persistent disease course.

Indexed as

Antirheumatic AgentsArthritis, JuvenileChildCohort StudiesData CollectionHumansRetrospective StudiesAntirheumatic AgentsBiologicsOutcomePredictorsSystemic onset juvenile idiopathic arthritisTreatment

Identifiers

PMID37679749
PMCPMC10485973
OpenAlexW4386498558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.