ArticleCardiovascular diabetology2023
Endogenous estradiol contributes to vascular endothelial dysfunction in premenopausal women with type 1 diabetes.
Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes.Diabetologia · 2025Trial
- Diabetes Type 2 in Women: The Impact of EndogenousOestrogen, A Population-Based Study With About 2 Decades of Follow-Up.Endocrinology, diabetes & metabolism · 2026Article
- Hidden Cardiovascular Risk: Early Menopause Triggering Acute Coronary Syndrome (ACS) in Young Patients.Cureus · 2026Article
- Carotid plaque formation prediction model and validation: a case-control study.Frontiers in cardiovascular medicine · 2026Article
- The Examination of Arterial Function and Mechanotransduction Through Brachial Arteries via Flow-Mediated Dilation.Advances in experimental medicine and biology · 2026Review
- Article
- Endothelial Reactive Oxygen Species: Key Players in Cardiovascular Health and Disease.Antioxidants & redox signaling · 2025Review
- Sex-Specific Associations of Prolactin and Progesterone With Glycemic Control in Adults With Type 1 Diabetes.Clinical medicine insights. Endocrinology and diabetes · 2025Article
- Determinants of vascular impairment in type 1 diabetes-impact of sex and connexin 37 gene polymorphism: A cross-sectional study.Cardiovascular diabetology · 2024Article
- Review
- Causal effects of glycemic traits and endometriosis: a bidirectional and multivariate mendelian randomization study.Diabetology & metabolic syndrome · 2024Article
- Sex differences in cardiovascular disease risk in type 1 diabetes: The vascular bed paradox in women.Diabetes & vascular disease researchArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEndogenous estrogen is cardio-protective in healthy premenopausal women. Despite this favorable action of estrogen, animal models depict a detrimental effect of estradiol on vascular function in the presence of diabetes. The present study sought to determine the role of endogenous estradiol on endothelial function in women with type 1 diabetes.
method32 women with type 1 diabetes (HbA
resultsOverall, estradiol was significantly increased during the LF phase compared to M in both type 1 diabetes (Δestradiol = 75 ± 86 pg/mL) and controls (Δestradiol = 71 ± 76 pg/mL); however, an increase in TBARS was only observed in patients with type 1 diabetes (ΔTBARS = 3 ± 13 µM) compared to controls (ΔTBARS = 0 ± 4 µM). FMD was similar (p = 0.406) between groups at M. In addition, FMD increased significantly from M to the LF phase in controls (p = 0.024), whereas a decrease was observed in type 1 diabetes. FMD was greater (p = 0.015) in patients using HBC compared to those not on HBC, independent of menstrual cycle phase.
conclusionEndogenous estradiol increases oxidative stress and contributes to endothelial dysfunction in women with diabetes. Additionally, HBC use appears to be beneficial to endothelial function in type 1 diabetes.
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