ArticleThe journal of headache and pain2023
Investigating the relationship between sleep and migraine in a global sample: a Bayesian cross-sectional approach.
Article in The journal of headache and pain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Interventions for Migraine and Sleep: A Systematic Review Exploring Their Bidirectional Association.European journal of neurology · 2026Pooled it
- Sleep macro- and microstructure in migraine and cluster headache: a systematic review of objective assessments.The journal of headache and pain · 2026Pooled it
- OnabotulinumtoxinA Improves Sleep Quality in Patients with Chronic Migraine: A Prospective Real-World Study.Toxins · 2026Observational
- Sleep Disorders in Medication-Overuse Headache: Prevalence and Associated Factors.European journal of neurology · 2026Article
- Beyond headache: non-cephalic pain, fatigue, and post-traumatic stress symptoms as longitudinal predictors of chronic migraine outcomes.Pain medicine (Malden, Mass.) · 2026Article
- Is it time to think about chronotherapy in migraine.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Shifts with Nights and Migraine Prevalence Among Nurses: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2026Review
- Associations of sleep, sedentary behavior, and physical activity with incident migraine: a prospective cohort study.BMC public health · 2026Article
- Epidemiology of primary headache and lifestyle factors among children and adolescents: a regional school-based study in China.The journal of headache and pain · 2026Article
- Prevalence, medication use, and health care utilization in pediatric primary headache: a school-based cross-sectional study.The journal of headache and pain · 2026Article
- Article
- Analysis of Sleep Quality and Its Associated Factors in Adolescents with Migraine.Journal of pain research · 2026Article
- The Correlation Between Migraine Frequency and Sleep Disturbances in Adults: A Cross-Sectional Study.Cureus · 2025Article
- Article
- Influence of next-generation artificial intelligence on headache research, diagnosis and treatment: the junior editorial board members' vision - part 2.The journal of headache and pain · 2025Review
- Global, regional, and national burden of headache disorders, 1990-2021, and projections to 2050: a comprehensive analysis of the global burden of disease study 2021.Frontiers in neurology · 2025Article
- Orexins and primary headaches: an overview of the neurobiology and clinical impact.Expert review of neurotherapeutics · 2024Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere is a bidirectional link between sleep and migraine, however causality is difficult to determine. This study aimed to investigate this relationship using data collected from a smartphone application.
methodsSelf-reported data from 11,166 global users (aged 18-81 years, mean: 41.21, standard deviation: 11.49) were collected from the Migraine Buddy application (Healint Pte. Ltd.). Measures included: start and end times of sleep and migraine attacks, and pain intensity. Bayesian regression models were used to predict occurrence of a migraine attack the next day based on users' deviations from average sleep, number of sleep interruptions, and hours slept the night before in those reporting ≥ 8 and < 25 migraine attacks on average per month. Conversely, we modelled whether attack occurrence and pain intensity predicted hours slept that night.
resultsThere were 724 users (129 males, 412 females, 183 unknown, mean age = 41.88 years, SD = 11.63), with a mean monthly attack frequency of 9.94. More sleep interruptions (95% Highest Density Interval (95%HDI [0.11 - 0.21]) and deviation from a user's mean sleep (95%HDI [0.04 - 0.08]) were significant predictors of a next day attack. Total hours slept was not a significant predictor (95%HDI [-0.04 - 0.04]). Pain intensity, but not attack occurrence was a positive predictor of hours slept.
conclusionsSleep fragmentation and deviation from typical sleep are the main drivers of the relationship between sleep and migraine. Having a migraine attack does not predict sleep duration, yet the pain associated with it does. This study highlights sleep as crucial in migraine management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.